{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:20:49Z","timestamp":1793409649001,"version":"4.5.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report findings from the 2021 Society for Hematopathology\/European Association for Haematopathology Workshop within the category of B-cell lineage neoplasms\u2019 transdifferentiation into histiocytic\/dendritic cell neoplasms (HDCNs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The workshop panel reviewed 29 cases, assigned consensus diagnoses, and summarized findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The specific diagnoses of transdifferentiated HDCN tumors were histiocytic sarcoma (16); Langerhans cell histiocytosis\/sarcoma (5); indeterminate DC tumor (1); and HDCN, unclassifiable (1). Approximately one-third of the patients reviewed had follicular lymphoma; lymphoblastic leukemia\/lymphoma; or another B-cell lymphoma, most commonly chronic lymphocytic leukemia\/small lymphocytic lymphoma. There was a 3:1 preponderance toward women, median patient age was 60 years, and the median interval between the initial diagnosis of B-cell lineage neoplasm and HDCN was 4 to 5 years. The submitted cases have demonstrated substantial heterogeneity as well as overlapping immunophenotypic and other features. Comprehensive genomic DNA sequencing revealed alterations enriched in the MAPK pathway. Based on shared and distinct alterations seen in HDCNs and the preceding lymphomas, both linear and divergent clonal evolutionary pathways were inferred. Furthermore, RNA sequencing performed in a subset of cases yielded new insights into markers that could be useful for more precise cell lineage identification. The panel has thus proposed an updated algorithm for HDCN lineage assignment. The outcome of transdifferentiated HDCNs was poor, but the MAPK signaling pathway emerges as a potentially attractive therapeutic target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transdifferentiated HDCNs demonstrate heterogeneity and pose diagnostic challenges with regard to exact classification, but the in-depth characterization of the submitted cases have added to our understanding of the secondary HDCNs transdifferentiated from B-cell lymphoma\/leukemia. Continuous efforts focusing on deciphering the specific cell lineage and differentiation state of these tumors will be critical for their accurate classification. Comprehensive molecular characterization of HDCNs may be informative in this regard. With the list of novel pharmacologic inhibitors of the MAPK pathway continuing to expand, improved outcomes for HDCN can be expected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad022","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T19:35:03Z","timestamp":1675884903000},"page":"522-537","source":"Crossref","is-referenced-by-count":21,"title":["B-cell lineage neoplasms transdifferentiating into histiocytic\/dendritic cell neoplasms: diversity, differentiation lineage, genomic alterations, and therapy: Report from the 2021 SH\/EAHP Workshop"],"prefix":"10.1093","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-8500","authenticated-orcid":false,"given":"Wenbin","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center , New York, NY , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Amador","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-8085","authenticated-orcid":false,"given":"James R","family":"Cook","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine Institute, Cleveland Clinic , Cleveland, OH , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Czader","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University School of Medicine , Indianapolis, IN , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Dave","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University School of Medicine , Durham, NC , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center , New York, NY , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Duffield","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center , New York, NY , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-8517","authenticated-orcid":false,"given":"John","family":"Goodlad","sequence":"additional","affiliation":[{"name":"Department of Pathology, NHS Greater Glasgow and Clyde , Glasgow , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Nejati","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fox Chase Cancer Center , Philadelphia, PA , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Robert-Bosch-Krankenhaus, and Dr Margarete Fischer-Bosch Institute for Clinical Pharmacology , Stuttgart , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Wasik","sequence":"additional","affiliation":[{"name":"Department of Pathology, Fox Chase Cancer Center , Philadelphia, PA , US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"issue":"(12)","key":"2023060108071019300_CIT0001","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1182\/blood-2007-11-124792","article-title":"Clonally related follicular lymphomas and histiocytic\/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone","volume":"111","author":"Feldman","year":"2008","journal-title":"Blood."},{"issue":"(3)","key":"2023060108071019300_CIT0002","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2350\/09-03-0622-OA.1","article-title":"Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature","volume":"13","author":"Castro","year":"2010","journal-title":"Pediatr Dev Pathol."},{"issue":"(22)","key":"2023060108071019300_CIT0003","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1182\/blood-2016-01-690636","article-title":"Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages","volume":"127","author":"Emile","year":"2016","journal-title":"Blood."},{"issue":"(11)","key":"2023060108071019300_CIT0004","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/modpathol.2011.102","article-title":"Clonally related histiocytic\/dendritic cell sarcoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a study of seven cases","volume":"24","author":"Shao","year":"2011","journal-title":"Mod Pathol."},{"issue":"(2)","key":"2023060108071019300_CIT0005","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41379-020-00673-x","article-title":"The mutational landscape of histiocytic sarcoma associated with lymphoid malignancy","volume":"34","author":"Egan","year":"2021","journal-title":"Mod Pathol."},{"issue":"(4)","key":"2023060108071019300_CIT0006","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00428-017-2176-1","article-title":"Histiocytic and dendritic cell neoplasms: what have we learnt by studying 67 cases","volume":"471","author":"Facchetti","year":"2017","journal-title":"Virchows Arch."},{"issue":"(2)","key":"2023060108071019300_CIT0007","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/blood-2017-10-812495","article-title":"Histiocytic sarcoma: a population-based analysis of incidence, demographic disparities, and long-term outcomes","volume":"131","author":"Kommalapati","year":"2018","journal-title":"Blood."},{"issue":"(7)","key":"2023060108071019300_CIT0008","doi-asserted-by":"crossref","first-page":"e1263","DOI":"10.1002\/onco.13801","article-title":"Histiocytic and dendritic cell sarcomas of hematopoietic origin share targetable genomic alterations distinct from follicular dendritic cell sarcoma","volume":"26","author":"Massoth","year":"2021","journal-title":"Oncologist"},{"issue":"(8)","key":"2023060108071019300_CIT0009","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol."},{"issue":"(7)","key":"2023060108071019300_CIT0010","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41590-018-0136-9","article-title":"Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells","volume":"19","author":"Rodrigues","year":"2018","journal-title":"Nat Immunol."},{"issue":"(4)","key":"2023060108071019300_CIT0011","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41590-022-01167-5","article-title":"Dntt expression reveals developmental hierarchy and lineage specification of hematopoietic progenitors","volume":"23","author":"Klein","year":"2022","journal-title":"Nat Immunol."},{"issue":"(7540)","key":"2023060108071019300_CIT0012","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature."},{"issue":"(1)","key":"2023060108071019300_CIT0013","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ni.3341","article-title":"The development and maintenance of resident macrophages","volume":"17","author":"Gomez Perdiguero","year":"2016","journal-title":"Nat Immunol."},{"issue":"(4)","key":"2023060108071019300_CIT0014","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.immuni.2018.09.023","article-title":"Adult connective tissue-resident mast cells originate from late erythro-myeloid progenitors","volume":"49","author":"Li","year":"2018","journal-title":"Immunity."},{"issue":"(4342)","key":"2023060108071019300_CIT0015","doi-asserted-by":"crossref","first-page":"eaag3009","DOI":"10.1126\/science.aag3009","article-title":"Mapping the human DC lineage through the integration of high-dimensional techniques","volume":"356","author":"See","year":"2017","journal-title":"Science."},{"issue":"(6335)","key":"2023060108071019300_CIT0016","doi-asserted-by":"crossref","first-page":"eaah4573","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science."},{"issue":"(5578)","key":"2023060108071019300_CIT0017","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1067518","article-title":"Reversion of B cell commitment upon loss of Pax5 expression","volume":"297","author":"Mikkola","year":"2002","journal-title":"Science."},{"issue":"(5)","key":"2023060108071019300_CIT0018","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(04)00419-2","article-title":"Stepwise reprogramming of B cells into macrophages","volume":"117","author":"Xie","year":"2004","journal-title":"Cell."},{"issue":"(1)","key":"2023060108071019300_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2559.2002.01418.x","article-title":"Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases","volume":"41","author":"Pileri","year":"2002","journal-title":"Histopathology."},{"issue":"(1)","key":"2023060108071019300_CIT0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(00)80160-0","article-title":"Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules","volume":"12","author":"Valladeau","year":"2000","journal-title":"Immunity."},{"issue":"(1)","key":"2023060108071019300_CIT0021","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/MCB.25.1.88-99.2005","article-title":"Disruption of the langerin\/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function","volume":"25","author":"Kissenpfennig","year":"2005","journal-title":"Mol Cell Biol."},{"issue":"(8)","key":"2023060108071019300_CIT0022","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1182\/blood-2017-01-761718","article-title":"High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis","volume":"130","author":"Papo","year":"2017","journal-title":"Blood."},{"issue":"(2)","key":"2023060108071019300_CIT0023","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1182\/blood-2016-12-757377","article-title":"Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem\/progenitor cells","volume":"130","author":"Durham","year":"2017","journal-title":"Blood."},{"issue":"(2)","key":"2023060108071019300_CIT0024","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2016-12-757823","article-title":"Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults","volume":"130","author":"Milne","year":"2017","journal-title":"Blood."},{"key":"2023060108071019300_CIT0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-immunol-093019-111748","article-title":"Origins, biology, and diseases of tissue macrophages","volume":"39","author":"Cox","year":"2021","journal-title":"Annu Rev Immunol."},{"issue":"(1)","key":"2023060108071019300_CIT0026","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.immuni.2012.04.012","article-title":"Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells","volume":"37","author":"Haniffa","year":"2012","journal-title":"Immunity."},{"issue":"(4)","key":"2023060108071019300_CIT0027","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1189\/jlb.1HI0714-351R","article-title":"Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells","volume":"97","author":"Bigley","year":"2015","journal-title":"J Leukoc Biol."},{"issue":"(12)","key":"2023060108071019300_CIT0028","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1097\/PAS.0b013e31818593d6","article-title":"Indeterminate cell tumor: a rare dendritic neoplasm","volume":"32","author":"Rezk","year":"2008","journal-title":"Am J Surg Pathol."},{"issue":"(8)","key":"2023060108071019300_CIT0029","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.0303-6987.2005.00382.x","article-title":"Indeterminate cell histiocytosis: fact or fiction?","volume":"32","author":"Ratzinger","year":"2005","journal-title":"J Cutan Pathol."},{"issue":"(8)","key":"2023060108071019300_CIT0030","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1001\/archderm.1988.01670080062020","article-title":"Unusual cutaneous histiocytosis expressing an intermediate immunophenotype between Langerhans\u2019 cells and dermal macrophages","volume":"124","author":"Berti","year":"1988","journal-title":"Arch Dermatol."},{"issue":"(2)","key":"2023060108071019300_CIT0031","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/cup.12611","article-title":"A case of indeterminate dendritic cell tumor presenting with leonine facies","volume":"43","author":"Oh","year":"2016","journal-title":"J Cutan Pathol."},{"issue":"(4)","key":"2023060108071019300_CIT0032","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1309\/M95G-7DQ2-TLQL-7Q11","article-title":"Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature","volume":"115","author":"Gaertner","year":"2001","journal-title":"Am J Clin Pathol."},{"issue":"(3)","key":"2023060108071019300_CIT0033","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.0309-0167.2004.01816.x","article-title":"Interdigitating dendritic cell sarcoma: a report of four paediatric cases and review of the literature","volume":"44","author":"Pillay","year":"2004","journal-title":"Histopathology."},{"key":"2023060108071019300_CIT0034","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.anndiagpath.2018.03.008","article-title":"Interdigitating dendritic cell sarcoma: clinicopathologic study of 8 cases with review of the literature","volume":"34","author":"Xue","year":"2018","journal-title":"Ann Diagn Pathol."},{"issue":"(8)","key":"2023060108071019300_CIT0035","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/01.pas.0000112536.76973.7f","article-title":"Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interdigitating dendritic cell tumors","volume":"28","author":"Grogg","year":"2004","journal-title":"Am J Surg Pathol."},{"issue":"(8)","key":"2023060108071019300_CIT0036","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/ajh.20852","article-title":"Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature","volume":"82","author":"Soriano","year":"2007","journal-title":"Am J Hematol."},{"issue":"(5)","key":"2023060108071019300_CIT0037","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1309\/7P8U659JBJCV6EEU","article-title":"Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors","volume":"128","author":"Yu","year":"2007","journal-title":"Am J Clin Pathol."},{"issue":"(3)","key":"2023060108071019300_CIT0038","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/path.2420","article-title":"Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma","volume":"216","author":"Vermi","year":"2008","journal-title":"J Pathol."},{"issue":"(4)","key":"2023060108071019300_CIT0039","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/107327481402100405","article-title":"Dendritic cell and histiocytic neoplasms: biology, diagnosis, and treatment","volume":"21","author":"Dalia","year":"2014","journal-title":"Cancer Control"},{"issue":"(1)","key":"2023060108071019300_CIT0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/modpathol.2015.130","article-title":"Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-\u03baB regulatory genes","volume":"29","author":"Griffin","year":"2016","journal-title":"Mod Pathol."},{"issue":"(3)","key":"2023060108071019300_CIT0041","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/PAS.0000000000001205","article-title":"SSTR2a is a useful diagnostic marker for follicular dendritic cells and their related tumors","volume":"43","author":"Tao","year":"2019","journal-title":"Am J Surg Pathol."},{"issue":"(1)","key":"2023060108071019300_CIT0042","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/PAS.0000000000001617","article-title":"Rosai-Dorfman disease displays a unique monocyte-macrophage phenotype characterized by expression of OCT2","volume":"45","author":"Ravindran","year":"2021","journal-title":"Am J Surg Pathol."},{"issue":"(11)","key":"2023060108071019300_CIT0043","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1182\/blood-2010-04-279083","article-title":"Recurrent BRAF mutations in Langerhans cell histiocytosis","volume":"116","author":"Badalian-Very","year":"2010","journal-title":"Blood."},{"issue":"(13)","key":"2023060108071019300_CIT0044","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1182\/blood-2012-05-430140","article-title":"High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses","volume":"120","author":"Haroche","year":"2012","journal-title":"Blood."},{"issue":"(10)","key":"2023060108071019300_CIT0045","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1182\/blood-2014-05-577361","article-title":"High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis","volume":"124","author":"Brown","year":"2014","journal-title":"Blood."},{"issue":"(19)","key":"2023060108071019300_CIT0046","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood-2014-05-577825","article-title":"Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis","volume":"124","author":"Chakraborty","year":"2014","journal-title":"Blood."},{"issue":"(12)","key":"2023060108071019300_CIT0047","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/s41591-019-0653-6","article-title":"Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms","volume":"25","author":"Durham","year":"2019","journal-title":"Nat Med."},{"issue":"(4)","key":"2023060108071019300_CIT0048","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/modpathol.2017.160","article-title":"The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort","volume":"31","author":"Ozkaya","year":"2018","journal-title":"Mod Pathol."},{"issue":"(4)","key":"2023060108071019300_CIT0049","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3324\/haematol.2019.230375","article-title":"Genomic profiling of primary histiocytic sarcoma reveals two molecular subgroups","volume":"105","author":"Egan","year":"2020","journal-title":"Haematologica."},{"key":"2023060108071019300_CIT0050","doi-asserted-by":"crossref","first-page":"11589","DOI":"10.1038\/ncomms11589","article-title":"Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition","volume":"7","author":"Burger","year":"2016","journal-title":"Nat Commun."},{"issue":"(9)","key":"2023060108071019300_CIT0051","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1038\/leu.2014.167","article-title":"Follicular lymphoma transformation into histiocytic sarcoma: indications for a common neoplastic progenitor","volume":"28","author":"Brunner","year":"2014","journal-title":"Leukemia."},{"issue":"(4)","key":"2023060108071019300_CIT0052","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/ajcp\/aqz056","article-title":"Histiocytic sarcoma following B-lymphoblastic leukemia\/lymphoma","volume":"152","author":"Geyer","year":"2019","journal-title":"Am J Clin Pathol."},{"issue":"(20)","key":"2023060108071019300_CIT0053","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1182\/blood-2015-08-665547","article-title":"Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy","volume":"127","author":"Gardner","year":"2016","journal-title":"Blood."},{"issue":"(58)","key":"2023060108071019300_CIT0054","doi-asserted-by":"crossref","first-page":"98723","DOI":"10.18632\/oncotarget.21920","article-title":"Prognostic factors for histiocytic and dendritic cell neoplasms","volume":"8","author":"Shimono","year":"2017","journal-title":"Oncotarget"},{"issue":"(10295)","key":"2023060108071019300_CIT0055","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(21)00311-1","article-title":"Histiocytosis","volume":"398","author":"Emile","year":"2021","journal-title":"Lancet."},{"issue":"(3)","key":"2023060108071019300_CIT0056","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/jamaoncol.2017.5029","article-title":"Vemurafenib for BRAF V600-mutant Erdheim-Chester disease and Langerhans cell histiocytosis: analysis of data from the histology-independent, phase 2, open-label VE-BASKET study","volume":"4","author":"Diamond","year":"2018","journal-title":"JAMA Oncol"},{"issue":"(7749)","key":"2023060108071019300_CIT0057","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41586-019-1012-y","article-title":"Efficacy of MEK inhibition in patients with histiocytic neoplasms","volume":"567","author":"Diamond","year":"2019","journal-title":"Nature."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/159\/6\/522\/50493459\/aqad022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/159\/6\/522\/50493459\/aqad022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T04:13:19Z","timestamp":1685592799000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/159\/6\/522\/7114957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,11]]},"references-count":57,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,4,11]]},"published-print":{"date-parts":[[2023,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqad022","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6,1]]},"published":{"date-parts":[[2023,4,11]]}}}