{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:44:04Z","timestamp":1790621044373,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["200798FK"],"award-info":[{"award-number":["200798FK"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Eye Foundation","award":["2021-04-20"],"award-info":[{"award-number":["2021-04-20"]}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["2021-0010"],"award-info":[{"award-number":["2021-0010"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Stockholm","award":["20200356"],"award-info":[{"award-number":["20200356"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Almost half of all patients diagnosed with uveal melanoma will die of metastatic disease. This has been attributed to early seeding of micrometastases. We investigate the presence, density, organ involvement, and characteristics of micrometastases of uveal melanoma in tissue obtained at autopsy of patients with and without coexisting macrometastases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients diagnosed with primary uveal melanoma at a national referral center between 1960 and 2020 (n = 4,282) were cross-referenced with autopsy registers at nearby hospitals. Eleven patients were included. Formalin-fixed, paraffin-embedded tissue samples obtained during autopsy were examined with routine histology, immunohistochemistry, and immunomagnetic separation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Micrometastases were detected in 5 of 5 patients with and in 5 of 6 patients without coexisting macrometastases. Micrometastases were identified in several sites, including lungs, kidneys, myocardium, and bone marrow. Their highest density per mm2 of tissue was seen in the liver. Of 11 examined patients, 2 had at least 1 BAP-1\u2013positive metastasis. All micrometastases had immune cell infiltrates and no or very low proliferative activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We demonstrate multiorgan involvement of apparently dormant micrometastases in patients with uveal melanoma. This suggests that micrometastases are present in nearly all patients diagnosed with primary uveal melanoma, regardless of coexisting macrometastases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad029","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T15:47:02Z","timestamp":1681400822000},"page":"164-174","source":"Crossref","is-referenced-by-count":30,"title":["Multiorgan Involvement of Dormant Uveal Melanoma Micrometastases in Postmortem Tissue From Patients Without Coexisting Macrometastases"],"prefix":"10.1093","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-3366","authenticated-orcid":false,"given":"Viktor T","family":"Gill","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Clinical Pathology, V\u00e4stmanland Hospital V\u00e4ster\u00e5s , V\u00e4ster\u00e5s , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Norrman","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, V\u00e4stmanland Hospital V\u00e4ster\u00e5s , V\u00e4ster\u00e5s , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Sabazade","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet , Stockholm , Sweden"},{"name":"St Erik Eye Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, V\u00e4stmanland Hospital V\u00e4ster\u00e5s , V\u00e4ster\u00e5s , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Lardner","sequence":"additional","affiliation":[{"name":"St Erik Eye Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-8911","authenticated-orcid":false,"given":"Gustav","family":"St\u00e5lhammar","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet , Stockholm , Sweden"},{"name":"St Erik Eye Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"2023080113013403000_CIT0001","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/bjophthalmol-2020-317949","article-title":"Patients presenting with metastases: stage IV uveal melanoma, an international study","volume":"106","author":"Garg","year":"2022","journal-title":"Br J Ophthalmol."},{"key":"2023080113013403000_CIT0002","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s43856-022-00082-y","article-title":"Long-term relative 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