{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:31:14Z","timestamp":1767339074032,"version":"3.37.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To summarize the conclusions of the 2021 Society for Hematopathology\/European Association for Haematopathology workshop regarding transformations of marginal zone lymphoma (MZL) and lymphoplasmacytic lymphoma (LPL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Nineteen cases were submitted to this portion of the workshop. Additional studies were performed in cases with sufficient material.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cases included splenic MZL (n = 4), splenic diffuse red pulp small B-cell lymphoma (n = 2), nodal MZL (n = 4), extranodal MZL (n = 1), and LPL (n = 8). The most common transformation was to diffuse large B-cell lymphoma (DLBCL), but others included classic Hodgkin lymphoma, high-grade B-cell lymphomas with MYC and BCL6 rearrangements, plasmablastic lymphoma, and plasma cell leukemia. Two splenic MZLs with transformation to DLBCL contained t(14;19)(q32;q13.3) IGH::BCL3 rearrangements in both samples. Paired sequencing studies in 5 MZLs with transformation to clonally related DLBCL identified a variety of mutations and gene fusions at the time of transformation, including CARD11, IGH::MYC, NOTCH2, P2RY8, TBLX1X1, and IGH::CD274.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Marginal zone lymphoma and LPL may undergo a variety of transformation events, most commonly to DLBCL, which is usually, although not always, directly clonally related to the underlying low-grade lymphoma. Multiparameter analysis including broad-based sequencing studies can assist in the diagnosis and classification of these uncommon cases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad034","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:34:09Z","timestamp":1682562849000},"page":"614-625","source":"Crossref","is-referenced-by-count":4,"title":["Transformations of marginal zone lymphomas and lymphoplasmacytic lymphomas: Report from the 2021 SH\/EAHP Workshop"],"prefix":"10.1093","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-8085","authenticated-orcid":false,"given":"James R","family":"Cook","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Robert J. 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Pathology, NHS Greater Glasgow and Clyde , Glasgow , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Robert-Borsch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology , Stuttgart , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8586-8500","authenticated-orcid":false,"given":"Wenbin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Medical Center , New York, NY , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Dave","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine , Durham, NC , 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