{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:35:51Z","timestamp":1777354551682,"version":"3.51.4"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert-Bosch-Stiftung, Stuttgart"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Session 4, \u201cTransformations of Follicular Lymphoma,\u201d and session 5, \u201cTransformations of Other B-Cell Lymphomas,\u201d included 45 cases. Gene alteration analysis and expression profiling were performed on cases with submitted formalin-fixed, paraffin embedded tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The findings from session 4 suggest that \u201cdiffuse large B-cell lymphoma\/high-grade B-cell lymphoma with rearrangements of MYC and BCL2\u201d is a distinct category arising from the constraints of a preexisting BCL2 translocation. TdT expression in aggressive B-cell lymphomas is associated with MYC rearrangements, immunophenotypic immaturity, and a dismal prognosis but must be differentiated from lymphoblastic \u00adlymphoma. Cases in session 5 illustrated unusual morphologic and immunophenotypic patterns of transformation. Additionally, the findings support the role of cytogenetic abnormalities\u2014specifically, MYC and NOTCH1 rearrangements\u2014as well as single gene alterations, including TP53, in transformation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Together, these unique cases and their accompanying molecular and cytogenetic data suggest potential mechanisms for and unusual patterns of transformation in B-cell lymphomas and indicate numerous opportunities for further study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad042","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T19:28:30Z","timestamp":1683833310000},"page":"572-597","source":"Crossref","is-referenced-by-count":9,"title":["Progression of follicular lymphoma and related entities: Report from the 2021 SH\/EAHP Workshop"],"prefix":"10.1093","volume":"159","author":[{"given":"Amy S","family":"Duffield","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center , New York, NY , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service, Memorial Sloan Kettering Cancer Center , New York, NY , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Amador","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-8085","authenticated-orcid":false,"given":"James R","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Robert J. 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