{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:32:42Z","timestamp":1779939162254,"version":"3.53.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aims to determine what pathologic and clinical factors differentiate Brachyspira species that may be useful to clinicians and pathologists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We identified 21 studies of Brachyspira infection with individual patient information (n = 113) and conducted a pooled analysis comparing each species.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were differences in the pathologic and clinical profiles of each Brachyspira species. Patients infected with Brachyspira pilosicoli infection were more likely to have diarrhea, fever, HIV, and immunocompromised conditions. Those patients infected with Brachyspira aalborgi were more likely to have lamina propria inflammation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our novel data provide potential insights into the pathogenic mechanism(s) and the specific risk factor profile of Brachyspira species. This may be clinically useful when assessing and managing patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad063","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T15:22:12Z","timestamp":1686237732000},"page":"335-340","source":"Crossref","is-referenced-by-count":5,"title":["Clinical and Pathologic Factors Associated With Colonic Spirochete (<i>Brachyspira pilosicoli<\/i> and <i>Brachyspira aalborgi<\/i>) Infection: A Comprehensive Systematic Review and Pooled Analysis"],"prefix":"10.1093","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1705","authenticated-orcid":false,"given":"Guy D","family":"Eslick","sequence":"first","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kening","family":"Fan","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema M","family":"Nair","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace L","family":"Burns","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C","family":"Hoedt","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Keely","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Talley","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Digestive Health, The University of Newcastle, Hunter Medical Research Institute (HMRI) , Callaghan , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"2023112805394403500_CIT0001","first-page":"e00087","article-title":"The spirochete Brachyspira pilosicoli, enteric pathogen of animals and humans","volume":"31","author":"Hampson","year":"2017","journal-title":"Clin Microbiol Rev."},{"key":"2023112805394403500_CIT0002","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1128\/jcm.16.6.1127-1136.1982","article-title":"Intestinal spirochetosis: morphological characterization and cultivation of the spirochete Brachyspira aalborgi gen. nov., sp. nov","volume":"16","author":"Hovind-Hougen","year":"1982","journal-title":"J Clin Microbiol."},{"key":"2023112805394403500_CIT0003","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1099\/00207713-46-1-206","article-title":"Serpulina pilosicoli sp. nov., the agent of porcine intestinal spirochetosis","volume":"46","author":"Trott","year":"1996","journal-title":"Int J Systemat Bacteriol"},{"key":"2023112805394403500_CIT0004","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0723-2020(00)80065-X","article-title":"Phylogenetic evidence for a novel and genetically different intestinal spirochetes resembling Brachyspira aalborgi in the mucosa of the human colon as revealed by 165 rDNA analysis","volume":"23","author":"Pettersson","year":"2000","journal-title":"Syst Appl Microbiol."},{"key":"2023112805394403500_CIT0005","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/bmj.3.5567.718","article-title":"Intestinal spirochetosis","volume":"3","author":"Harland","year":"1967","journal-title":"BMJ."},{"key":"2023112805394403500_CIT0006","doi-asserted-by":"crossref","first-page":"e00465","DOI":"10.1128\/JB.00465-19","article-title":"Hiding in plain sight: colonic spirochetosis in humans","volume":"201","author":"Norris","year":"2019","journal-title":"J Bacteriol."},{"key":"2023112805394403500_CIT0007","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/0956462420958350","article-title":"Human intestinal spirochetosis, a sexually transmissible infection? 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