{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T13:54:36Z","timestamp":1785678876865,"version":"3.56.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>TRPS1 is a new, sensitive marker for breast carcinoma (BC). Salivary glands and breasts are both exocrine glands; thus, their tumors may share similar morphology and immunophenotype. Among salivary gland\u2013type BC, TRPS1 is reported to be positive in secretory carcinomas (SCs) but negative in acinic cell carcinomas (AciCCs) and most adenoid cystic carcinomas (AdCCs). A subset of salivary duct carcinomas (SDCs) is positive for TRPS1. Herein, we investigate TRPS1 immunohistochemical expression in salivary gland tumors (SGTs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective search yielded 110 SGTs (97 primary and 13 metastatic). TRPS1 immunohistochemistry was scored as negative, low positive, intermediate positive, or strongly positive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>TRPS1 was expressed in 78% (14\/18) of pleomorphic adenoma (PA) cases but negative\/low positive in all Warthin tumors (6\/6 [100%]). In basal cell adenoma (BCA), TRPS1 expression was intermediate to strong (13\/14 [92%]) in the stromal cells, whereas ductal or basal cells showed low expression. TRPS1 expression varied in malignant SGTs, with intermediate to strong staining in 100% (15\/15) of AdCCs, 100% (5\/5) of basal cell adenocarcinoma, 100% (3\/3) of intraductal carcinoma, 89% (8\/9) of polymorphous adenocarcinoma, and 89% (7\/8) of SDCs; negative\/low positive expression was observed in 100% (3\/3) of SCs, 89% (8\/9) of AciCCs, and 50% (3\/3) of mucoepidermoid carcinomas. In addition, strong and intermediate TRPS1 expression was observed in metastatic SGT to the lungs, lymph nodes, and soft tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, TRPS1 is strongly expressed in PA as well as malignant and metastatic SGT. In addition, TRPS1 is positive in stromal cells of BCA but negative or low positive in ductal and basal cells.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad100","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T12:55:37Z","timestamp":1691758537000},"page":"633-639","source":"Crossref","is-referenced-by-count":15,"title":["TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study"],"prefix":"10.1093","volume":"160","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-312X","authenticated-orcid":false,"given":"Youley","family":"Tjendra","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-2044","authenticated-orcid":false,"given":"Darcy A","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine , Lebanon, NH , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-2428","authenticated-orcid":false,"given":"Carmen","family":"Gomez-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL , US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-2748","authenticated-orcid":false,"given":"Jaylou M","family":"Velez Torres","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL , US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"2023120112205077600_CIT0001","first-page":"7677","article-title":"A central role for TRPS1 in the control of cell cycle and cancer development","volume-title":"Oncotarget.","author":"Wu","year":"2014"},{"key":"2023120112205077600_CIT0002","first-page":"132","article-title":"Expression and relevance of TRPS-1: a new GATA transcription factor in breast cancer","volume-title":"Horm Cancer","author":"Chen","year":"2011"},{"key":"2023120112205077600_CIT0003","first-page":"179","article-title":"TRPS1 acts as a context-dependent regulator of mammary epithelial cell growth\/differentiation and breast cancer development","volume-title":"Genes Dev.","author":"Cornelissen","year":"2020"},{"key":"2023120112205077600_CIT0004","first-page":"710","article-title":"TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative 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rearrangement distinguishes a subset of uterine myxoid leiomyosarcoma from other uterine myxoid mesenchymal tumors","volume-title":"Am J Surg Pathol.","author":"Arias-Stella","year":"2019"},{"key":"2023120112205077600_CIT0017","first-page":"1030","article-title":"Some pleomorphic adenomas of the breast share PLAG1 rearrangements with the analogous tumour of the salivary glands","volume-title":"Histopathology.","author":"Ma","year":"2021"},{"key":"2023120112205077600_CIT0018","first-page":"237","article-title":"NDRG1-PLAG1 and TRPS1-PLAG1 fusion genes in chondroid syringoma","volume-title":"Cancer Genomics Proteomics","author":"Panagopoulos","year":"2020"},{"key":"2023120112205077600_CIT0019","first-page":"609","article-title":"Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma","volume-title":"Mod Pathol.","author":"Zhu","year":"2019"},{"key":"2023120112205077600_CIT0020","first-page":"73","article-title":"Expression of TRPS1 in phyllodes tumor and sarcoma of the breast","volume-title":"Hum Pathol.","author":"Wang","year":"2022"},{"key":"2023120112205077600_CIT0021","first-page":"586","article-title":"Wnt\/\u03b2-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland","volume-title":"Pathol Res Pract.","author":"Sato","year":"2018"},{"key":"2023120112205077600_CIT0022","first-page":"1143","article-title":"Distinctive patterns of CTNNB1 (\u03b2-catenin) alterations in salivary gland basal cell adenoma and basal cell adenocarcinoma","volume-title":"Am J Surg Pathol.","author":"Jo","year":"2016"},{"key":"2023120112205077600_CIT0023","first-page":"778","article-title":"Molecular analysis of chromosome 16q regions in dermal analogue tumors of salivary glands: a genetic link to dermal 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