{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:06:46Z","timestamp":1775725606721,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK119584"],"award-info":[{"award-number":["K23DK119584"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess if the distribution of villous intraepithelial lymphocytes (IELs) in a pediatric cohort with Marsh I histopathology is specific to celiac disease (CeD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Multicenter, retrospective case-control study between January 2001 and December 2019 in children (&amp;lt;18 years) with and without CeD with intraepithelial lymphocytosis and normal villous architecture. Pathology specimens were reviewed by 2 study pathologists who were blinded to the final diagnosis. Morphologic features (villous height to crypt depth ratio [Vh:Cd]) and IELs in the villous tip, top, or bottom half of the villus were quantified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 97 children with Marsh I histopathology identified during the study period, 63 were excluded due to an insufficient number of well-oriented villous-crypt complexes or a Vh:Cd less than 2. Villous IELs were measured in 34 cases (14 CeD, 20 non-CeD controls). There was no difference between the non-CeD and CeD groups in the mean IELs at the villous tip (14.0 \u00b1 7.1 vs 11.7 \u00b1 6.0, P = .31), top (46.4 \u00b1 18.4 vs 38.3 \u00b1 10.8, P = .11), or bottom (29.8 \u00b1 16.8 vs 28.5 \u00b1 12.8, P = .80) half of each villus, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The distribution of IELs in Marsh I lesions is not specific for CeD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad124","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:26:44Z","timestamp":1696354004000},"page":"149-154","source":"Crossref","is-referenced-by-count":2,"title":["A tip-predominant distribution of villous intraepithelial lymphocytes is not specific to celiac disease in children with Marsh I lesions"],"prefix":"10.1093","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-5785","authenticated-orcid":false,"given":"Denis","family":"Chang","sequence":"first","affiliation":[{"name":"Harvard Celiac Research Program, Harvard Medical School , Boston, MA , US"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children\u2019s Hospital , Boston, MA , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte F","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Texas Children\u2019s Hospital , Houston, TX , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Horton","sequence":"additional","affiliation":[{"name":"Harvard Celiac Research Program, Harvard Medical School , Boston, MA , US"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children\u2019s Hospital , Boston, MA , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology and Hepatology, Seattle Children\u2019s Hospital , Seattle, WA , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Cristina","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Seattle Children\u2019s Hospital , Seattle, WA , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn A","family":"Silvester","sequence":"additional","affiliation":[{"name":"Harvard Celiac Research Program, Harvard Medical School , Boston, MA , US"},{"name":"Division of Gastroenterology, Hepatology and Nutrition, Boston Children\u2019s Hospital , Boston, MA , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D","family":"Goldsmith","sequence":"additional","affiliation":[{"name":"Harvard Celiac Research Program, Harvard Medical School , Boston, MA , US"},{"name":"Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School , Boston, MA , US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"2024020116351648700_CIT0001","first-page":"51","article-title":"Duodenal intraepithelial lymphocytosis with normal villous architecture in pediatric patients: Mayo Clinic experience, 2000-2009","volume-title":"J Pediatr Gastroenterol Nutr.","author":"Shmidt","year":"2013"},{"key":"2024020116351648700_CIT0002","first-page":"186","article-title":"Celiac disease: histology-differential diagnosis-complications. 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