{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:49:41Z","timestamp":1790776181308,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Myeloid\/lymphoid neoplasms with FGFR1 rearrangement are a rare group of neoplasms that share features of eosinophilia and lineage promiscuity. First, we described a challenging case of acute leukemia with lineage switch and cytogenetically cryptic FGFR1. Second, we aimed to systemically review this phenomenon in published literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A 68-year-old man with a history of chemotherapy exposure presented with acute leukemia of myeloid lineage without eosinophilia or 8p11 abnormalities on karyotyping. Over a refractory and relapsing course, the blast phenotype shifted to B lymphoid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fluorescence in situ hybridization identified a cytogenetically cryptic FGFR1 rearrangement, likely a paracentric inversion. We identified 26 published cases of FGFR1-rearranged acute leukemia with ambiguous, mixed, or switching lineage. Although there was variability in the partner gene, anatomical location of different phenotypes, and timing of lineage switch, the prognosis was consistently poor in the absence of novel therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ours is the only reported case of FGFR1-rearranged neoplasms with a disease sequence of acute myeloid leukemia transforming to B-cell acute lymphoblastic leukemia and 1 of only 3 reported cases with cytogenetically cryptic FGFR1 rearrangement. Fluorescence in situ hybridization testing for FGFR1 rearrangement should be a standard investigation in leukemia of mixed or switching lineage.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad135","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T17:19:18Z","timestamp":1697735958000},"page":"197-205","source":"Crossref","is-referenced-by-count":7,"title":["Acute leukemia with cytogenetically cryptic <i>FGFR1<\/i> rearrangement and lineage switch during therapy: A case report and literature review"],"prefix":"10.1093","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0120","authenticated-orcid":false,"given":"Sean J","family":"McKeague","sequence":"first","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacey","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Fanning","sequence":"additional","affiliation":[{"name":"Icon Cancer Centre, Mater Hospital , South Brisbane , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Joy","sequence":"additional","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Throp","sequence":"additional","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Adams","sequence":"additional","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Harvey","sequence":"additional","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tee Beng","family":"Keng","sequence":"additional","affiliation":[{"name":"Haematology Department, Sullivan Nicolaides Pathology , Bowen Hills , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"2024020116350825000_CIT0001","first-page":"160","article-title":"Myeloid\/lymphoid neoplasms associated with eosinophilia and rearrangements of PDGFRA, PDGFRB, or FGFR1 or with 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Lymphoma.","author":"Manur","year":"2020"},{"key":"2024020116350825000_CIT0020","first-page":"71","article-title":"Translocation (8;13) and T-cell lymphoma. 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