{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:05:10Z","timestamp":1790280310011,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Microvascular invasion (MVI) has previously been reported to be related to cancer prognosis; however, its significance in patients with dual-phenotype hepatocellular carcinoma (DPHCC) remains uncharacterized. We studied the role of MVI in the survival of patients diagnosed with DPHCC in Fujian, China, which has a high incidence of HCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with DPHCC (n = 84) who had undergone surgical interventions at the 900th Hospital of the Joint Logistic Support Force between 2013 and 2019 were retrospectively analyzed using the log-rank test and Kaplan-Meier method. Univariate and multivariate Cox model analyses were also conducted to further understand the correlation between MVI and patient survival.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our results indicated that MVI was related to poor survival. According to the univariate analysis, MVI, the number of tumor lesions, necrosis, differentiation, peripheral hepatic fibrosis, the expression of cytokeratin 19 (CK19), and serum levels of both \u0251-fetoprotein (AFP) and cancer antigen-199 showed a strong correlation with overall survival. Necrosis and serum AFP levels were strongly related to an increased risk of death, according to the multivariate analysis. Tumor size; the number of tumor lesions; differentiation; peripheral hepatic fibrosis; liver capsule invasion; and expression of CK19, vascular endothelial growth factor, CK7, and mucin 1 showed a correlation with MVI, per the outcomes of \u03c72 tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Microvascular invasion may correlate with the survival of patients with DPHCC and could potentially serve as a prognostic predictor of survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqad143","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T10:44:17Z","timestamp":1699613057000},"page":"245-255","source":"Crossref","is-referenced-by-count":11,"title":["Microvascular invasion is associated with poor survival in patients with dual-phenotype hepatocellular carcinoma"],"prefix":"10.1093","volume":"161","author":[{"given":"Xiaojuan","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Pathology , 900th Hospital of the Joint Logistics Support Force, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology , 900th Hospital of the Joint Logistics Support Force, Fuzhou, China"},{"name":"Fuzong Clinical Medical College of Fujian Medical University , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology , 907th Hospital of the Joint Logistics Support Force, Nanping, Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology , 900th Hospital of the Joint Logistics Support Force, Fuzhou, China"},{"name":"Fuzong Clinical Medical College of Fujian Medical University , Fuzhou , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology , 900th Hospital of the Joint Logistics Support Force, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology , 900th Hospital of the Joint Logistics Support Force, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"2024030111170322300_CIT0001","first-page":"209","article-title":"Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume-title":"CA Cancer J 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indicated poor prognosis in hepatocellular carcinoma via driving epithelial-mesenchymal transition","volume-title":"J Cancer.","author":"Song","year":"2018"},{"key":"2024030111170322300_CIT0018","first-page":"360","article-title":"Hepatocellular carcinoma with macrovascular invasion: defining the optimal treatment strategy","volume-title":"Liver Cancer.","author":"Costentin","year":"2017"},{"key":"2024030111170322300_CIT0019","first-page":"1053","article-title":"Microvascular invasion in small-sized hepatocellular carcinoma: significance for outcomes following hepatectomy and radiofrequency ablation","volume-title":"Anticancer Res.","author":"Imai","year":"2018"},{"key":"2024030111170322300_CIT0020","first-page":"197","article-title":"Microvascular invasion of single small hepatocellular carcinoma \u22643 cm: predictors and optimal treatments","volume-title":"Ann Gastroenterol Surg.","author":"Yamashita","year":"2018"},{"key":"2024030111170322300_CIT0021","first-page":"61203","article-title":"Prognostic value and preoperative predictors of microvascular invasion in solitary hepatocellular carcinoma \u22645 cm without macrovascular invasion","volume-title":"Oncotarget.","author":"Zhao","year":"2017"},{"key":"2024030111170322300_CIT0022","first-page":"1047","article-title":"Preoperative circulating tumor cells to predict microvascular invasion and dynamical detection indicate the prognosis of hepatocellular carcinoma","volume-title":"BMC Cancer.","author":"Zhou","year":"2020"},{"key":"2024030111170322300_CIT0023","first-page":"9037","article-title":"Nomogram for preoperative prediction of microvascular invasion risk in hepatocellular carcinoma","volume-title":"Cancer Manag Res.","author":"Deng","year":"2019"},{"key":"2024030111170322300_CIT0024","first-page":"2737","article-title":"Liver resection is justified in patients with BCLC intermediate stage hepatocellular carcinoma without microvascular invasion","volume-title":"J Gastrointest Surg.","author":"Wang","year":"2019"},{"key":"2024030111170322300_CIT0025","first-page":"79722","article-title":"Preoperative neutrophil to lymphocyte ratio and tumor-related factors to predict microvascular invasion in patients with hepatocellular carcinoma","volume-title":"Oncotarget.","author":"Yu","year":"2017"},{"key":"2024030111170322300_CIT0026","first-page":"887","article-title":"Risk factors of recurrence and poor survival in curatively resected hepatocellular carcinoma with microvascular invasion","volume-title":"Adv Clin Exp Med.","author":"Zhou","year":"2020"},{"key":"2024030111170322300_CIT0027","first-page":"304","article-title":"Hepatitis B virus infection and active replication promote the formation of vascular invasion in hepatocellular carcinoma","volume-title":"BMC Cancer.","author":"Wei","year":"2017"},{"key":"2024030111170322300_CIT0028","first-page":"278","article-title":"The 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