{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:01:29Z","timestamp":1788559289370,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Henan Province","award":["LHGJ20190332"],"award-info":[{"award-number":["LHGJ20190332"]}]},{"name":"Henan Province","award":["LHGJ20210445"],"award-info":[{"award-number":["LHGJ20210445"]}]},{"name":"Science and Technology Research Project of Henan Province","award":["232102310155"],"award-info":[{"award-number":["232102310155"]}]},{"name":"Science and Technology Development Plan of Henan Province","award":["242102521036"],"award-info":[{"award-number":["242102521036"]}]},{"name":"Higher Education Key Scientific Research Plan of Henan Province","award":["22A320007"],"award-info":[{"award-number":["22A320007"]}]},{"name":"Henan Province Medical Science and technology research plan","award":["SBGJ202101020"],"award-info":[{"award-number":["SBGJ202101020"]}]},{"name":"Elite, Niche, and Unique Disciplinary Support Program","award":["XKLMJX202214"],"award-info":[{"award-number":["XKLMJX202214"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate optical coherence microscopy (OCM) imaging features and the application value of these high-resolution images for identifying endocervical canal lesions (ECLs), which is a clinical dilemma in cervical cancer screening programs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 520 OCM images were obtained by scanning the cervical canal lesions with an ultra-high-resolution OCM system (204 specimens from 73 patients). The OCM morphologic characteristics of ECLs were observed and summarized, and then 3 researchers performed a diagnostic test of OCM images of cervical canal lesions. The accuracy, sensitivity, specificity, positive predictive value, negative predictive value, 95% confidence interval of each parameter, and interinvestigator agreement (\u03ba) were calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Normal endocervix, cysts, squamous metaplasia, high-grade squamous intraepithelial lesions involving glands, and invasive carcinoma had distinct OCM characteristics, which correlated well with corresponding H&amp;E histologic sections. The accuracy, sensitivity, and specificity of the 3 researchers were 90.6%, 89.3% (95% CI, 86.5%-91.7%) and 91.6% (95% CI, 89.2%-93.5%), respectively. The positive predictive value was 90.1% (95% CI, 87.3%-92.4%), and the negative predictive value was 90.9% (95% CI, 88.5%-92.9%), with almost perfect agreement (\u03ba = 0.874).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The application of the OCM system in cervical canal lesions is feasible and could help improve detection of occult ECLs in cervical cancer screening programs. This study lays the foundation for further research on OCM in cervical canal lesions in vivo, which also has a potential impact on projecting pathologic evaluation beyond what is currently possible, perhaps globally.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae052","type":"journal-article","created":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T03:20:10Z","timestamp":1714879210000},"page":"392-400","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics and utility of high-resolution optical coherence microscopy images of endocervical canal lesions"],"prefix":"10.1093","volume":"162","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology, The Third Affiliated Hospital of Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Radiology, The Third Affiliated Hospital of Zhengzhou University , Zhengzhou ,","place":["China"]},{"name":"Department of Gynecology, The Third 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