{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:44:57Z","timestamp":1792820697447,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Severe macrovesicular steatosis in donor livers is associated with primary graft dysfunction. The Banff Working Group on Liver Allograft Pathology has proposed recommendations for steatosis assessment of donor liver biopsy specimens with a consensus for defining \u201clarge droplet fat\u201d (LDF) and a 3-step algorithmic approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrieved slides and initial pathology reports from potential liver donor biopsy specimens from 2010 to 2021. Following the Banff approach, we reevaluated LDF steatosis and employed a computer-assisted manual quantification protocol and artificial intelligence (AI) model for analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a total of 113 slides from 88 donors, no to mild (&amp;lt;33%) macrovesicular steatosis was reported in 88.5% (100\/113) of slides; 8.8% (10\/113) was reported as at least moderate steatosis (\u226533%) initially. Subsequent pathology evaluation, following the Banff recommendation, revealed that all slides had LDF below 33%, a finding confirmed through computer-assisted manual quantification and an AI model. Correlation coefficients between pathologist and computer-assisted manual quantification, between computer-assisted manual quantification and the AI model, and between the AI model and pathologist were 0.94, 0.88, and 0.81, respectively (P &amp;lt; .0001 for all).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The 3-step approach proposed by the Banff Working Group on Liver Allograft Pathology may be followed when evaluating steatosis in donor livers. The AI model can provide a rapid and objective assessment of liver steatosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae053","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T10:34:30Z","timestamp":1715164470000},"page":"401-407","source":"Crossref","is-referenced-by-count":13,"title":["Artificial intelligence\u2013aided steatosis assessment in donor livers according to the Banff consensus recommendations"],"prefix":"10.1093","volume":"162","author":[{"given":"Jingjing","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Pathology, Yale School of Medicine , New Haven, CT ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-349X","authenticated-orcid":false,"given":"Haiming","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale School of Medicine , New Haven, CT 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