{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:51:49Z","timestamp":1777045909861,"version":"3.51.4"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The incidence of pituitary neuroendocrine tumors has been reported high at autopsy. This study aimed to detect many tumors in both anterior and posterior lobes to prove tumor histogenesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 150 pituitary glands were studied from the University of Kansas Medical Center from 1995 to 2000. The pituitary gland was sagittally sliced from anterior to posterior into 6 to 8 sections. When H&amp;E-stained sections revealed tumors, the tumors were immunohistochemically stained for 6 pituitary hormones.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 150 autopsy cases, 38 (25.3%) harbored microadenomas, including 4 cases with double tumors. Twenty-three (54.7%) cases were negative to all pituitary hormones. Of the remaining 19 tumors, 13 (30.9%) were lactotrophs, with 4 cases being concomitantly somatotrophs and gonadotrophs, and 2 cases were corticotropes. More than 85% of pituitary neuroendocrine tumors were adjacent to the capsule. Thirteen (8.7%) granular cell pituicytomas were found in the posterior lobe. There were pituicytes transforming into granular cell tumors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The incidence was 25.3% for pituitary neuroendocrine tumors and 8.7% for granular cell pituicytomas. Since most pituitary neuroendocrine tumors were adjacent to the pituitary capsule, the capsule appeared to be the germinal center. Both pituitary tumors belonged to the 2 different transcription factor lineages.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae067","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T19:25:17Z","timestamp":1719257117000},"page":"509-520","source":"Crossref","is-referenced-by-count":2,"title":["Pituitary neuroendocrine tumors and granular cell pituicytomas at autopsy: Incidence, cell types, locations, and histogenesis in 150 pituitary glands"],"prefix":"10.1093","volume":"162","author":[{"given":"Tatsuo","family":"Tomita","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center , Kansas City, KS ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Gates","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center , Kansas City, KS ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"issue":"1","key":"2024110408210979700_CIT0001","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/geronj\/35.1.16","article-title":"Pituitary adenoma in old age","volume":"35","author":"Kovacs","year":"1980","journal-title":"J Gerontol"},{"key":"2024110408210979700_CIT0002","first-page":"137","article-title":"Pituitary adenoma: surgical versus postmortem finding today","volume-title":"Pituitary Microadenoma.","author":"Mosca","year":"1980"},{"issue":"8","key":"2024110408210979700_CIT0003","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1212\/WNL.31.8.998","article-title":"Pituitary metastasis: incidence in cancer patients and clinical differentiation from pituitary adenoma","volume":"31","author":"Max","year":"1981","journal-title":"Neurology."},{"issue":"2","key":"2024110408210979700_CIT0004","first-page":"228","article-title":"Incidental pituitary adenoma","volume":"54","author":"Parent","year":"1981","journal-title":"J Neurol."},{"issue":"2","key":"2024110408210979700_CIT0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2214\/ajr.137.2.213","article-title":"Sellar contour: anatomic-polymorphic correlation","volume":"137","author":"Turski","year":"1981","journal-title":"AJR Am J Roentgenol."},{"issue":"2","key":"2024110408210979700_CIT0006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00342982","article-title":"Parallel study on the roentgen anatomy of the sella turcica and histopathology of the pituitary in 205 autopsy specimens","volume":"21","author":"Muhr","year":"1981","journal-title":"Neuroradiology."},{"issue":"3","key":"2024110408210979700_CIT0007","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1056\/NEJM198101153040306","article-title":"Microadenoma of the pituitary and abnormal sellar tomograms in unselected autopsy cases","volume":"304","author":"Burrow","year":"1981","journal-title":"N Eng J Med."},{"issue":"2","key":"2024110408210979700_CIT0008","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3171\/jns.1981.54.2.0228","article-title":"Incidental pituitary adenomas","volume":"54","author":"Parent","year":"1981","journal-title":"J Neurosurg."},{"issue":"9","key":"2024110408210979700_CIT0009","first-page":"488","article-title":"Subclinical adenoma of the human pituitary: new light on old problems","volume":"107","author":"McComb","year":"1983","journal-title":"Arch Path Lab Med."},{"issue":"40","key":"2024110408210979700_CIT0010","first-page":"2747","article-title":"Latent pituitary adenoma: autopsy study [in French]","volume":"59","author":"Coulon","year":"1983","journal-title":"Sem Hosp."},{"issue":"2","key":"2024110408210979700_CIT0011","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0090-3019(84)90040-5","article-title":"Subclinical pituitary microadenomas","volume":"22","author":"Sigueira","year":"1984","journal-title":"Surg Neurol."},{"issue":"3","key":"2024110408210979700_CIT0012","first-page":"464","article-title":"Pituitary adenomas: an immunohistochemical study of hormone production and chromogranin localization","volume":"116","author":"Stephano","year":"1984","journal-title":"Am J Pathol."},{"key":"2024110408210979700_CIT0013","article-title":"Asymptomatic microadenomas of the pituitary gland in unselected autopsy series. 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