{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:05:19Z","timestamp":1792123519437,"version":"4.4.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313663"],"award-info":[{"award-number":["2018A030313663"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Science and Technology Program of Guangdong Province","award":["A 2018001"],"award-info":[{"award-number":["A 2018001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Primary intestinal T-cell and natural killer\u2013cell lymphomas (PITNKLs) are aggressive and make pathologic diagnoses in biopsy specimens challenging. We analyzed different subtypes\u2019 clinicopathologic features and treatment outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Seventy-nine PITNKL cases were characterized by clinical, morphologic, and immunohistochemical features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 79 cases of PITNKLs from 2008 to 2017 in our institution, 40 (50.63%) were extranodal NK\/T-cell lymphoma, nasal type (ENKTL); 32 (40.51%) monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL); 6 (7.59%) intestinal T-cell lymphoma, not otherwise specified; and 1 (1.27%) indolent T-cell lymphoma of the gastrointestinal tract. Small intestine (n = 47) was the most common site. Monomorphic epitheliotropic intestinal T-cell lymphoma showed distinctive clinicopathologic features from other subtypes with high expression (96.88%) of spleen tyrosine kinase (SYK) and PD-L1 (87.5%) and the poorest prognosis (P &amp;lt; .001). CD30 was highly expressed in ENKTL (9\/17, 57.94%) and irrelevant to prognosis (P &amp;gt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Cases of PITNKL are biologically heterogeneous; most have a dismal prognosis. SYK and PD-L1 expression might be a significant marker for MEITL and helps differential diagnosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae102","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T05:18:42Z","timestamp":1720847922000},"page":"121-133","source":"Crossref","is-referenced-by-count":8,"title":["Primary intestinal T-cell and natural killer\u2013cell lymphomas: Clinicopathologic and prognostic features of 79 cases in South China"],"prefix":"10.1093","volume":"163","author":[{"given":"Na","family":"Guo","sequence":"first","affiliation":[{"name":"Zhejiang Cancer Hospital Ringgold , Hangzhou, Zhejiang ,","place":["China"]},{"name":"Chinese Academy of Sciences Ringgold , Beijing, Zhejiang ,","place":["China"]},{"name":"Department of Pathology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong ,","place":["China"]},{"name":"Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center Ringgold , Guangzhou, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong 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