{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:16:10Z","timestamp":1790882170126,"version":"4.1.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The objective of this study was to evaluate SOX17, a transcription factor from the Sry high-mobility group\u2013related box superfamily, as a diagnostic marker to determine site of origin using both whole-tissue sections and tissue microarrays (TMAs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>SOX17 immunohistochemistry was performed on gynecologic and nongynecologic tissues (N = 1004) using whole-tissue sections and both internally constructed and commercially available TMAs. SOX17 nuclear reactivity was scored as positive or negative on the whole-tissue sections and using the semiquantitative H score method on TMAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Using both whole-tissue sections and TMAs, SOX17 was positive in 94% (n = 155) of endometrial tumors and 96% (n = 242) of ovarian tumors. All breast cases (n = 241) and vulvar\/cervical squamous cell carcinomas (n = 150) were negative. Among 1004 tumors from 20 sites, the only organs with positive tumors were ovary, uterus, and testis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SOX17 is a sensitive and specific marker for gynecologic origin in the tissues tested and may be a valuable adjunct to PAX8 and other commonly used markers to confirm endometrial or ovarian origin. SOX17 expression is lower in mucinous tumors, endocervical adenocarcinoma, high-grade neuroendocrine tumors, and undifferentiated\/dedifferentiated endometrial carcinoma.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae104","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T22:24:29Z","timestamp":1721082269000},"page":"143-152","source":"Crossref","is-referenced-by-count":8,"title":["A comprehensive analysis of SOX17 expression by immunohistochemistry in human epithelial tumors, with an emphasis on gynecologic tumors"],"prefix":"10.1093","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-8294","authenticated-orcid":false,"given":"Beth Z","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Rinda","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Elishaev","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri E","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirka W","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren B","family":"Skvarca","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh A","family":"Motanagh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria J","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-8014","authenticated-orcid":false,"given":"Jeffrey L","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Harinath","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine, UPMC Magee-Womens Hospital , Pittsburgh, PA 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