{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:38:22Z","timestamp":1789663102151,"version":"4.0.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute myeloid leukemia with CBFA2T3::GLIS2 fusion can initially present as extramedullary lesions (myeloid sarcoma), leading to a misdiagnosis of nonhematologic pediatric solid tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We characterized the clinicopathologic features of 4 cases of CBFA2T3::GLIS2 fusion-positive myeloid sarcoma in pediatric patients where the sarcoma presented either without leukemic involvement (isolated myeloid sarcoma; 3\/4 [75%]) or had concurrent leukemic disease (1\/4 [25%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All cases mimicked nonhematopoietic tumors at morphologic and immunophenotypic levels, so the initial evaluation did not raise suspicion for acute myeloid leukemia\/myeloid sarcoma. After extensive workup, however, including molecular studies, the diagnosis of myeloid sarcoma with CBFA2T3::GLIS2 fusion was rendered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study highlights the need for a high suspicion index of GLIS2-rearranged myeloid sarcoma in the differential diagnosis of pediatric small round cell tumors in tissue biopsies and the application of adequate workup to avoid misdiagnosing this entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae131","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T16:27:16Z","timestamp":1725726436000},"page":"377-387","source":"Crossref","is-referenced-by-count":4,"title":["Myeloid sarcomas with\n                    <i>CBFA2T3<\/i>\n                    :\n                    <i>GLIS2<\/i>\n                    fusion: clinicopathologic characterization of 4 cases mimicking small round cell tumors"],"prefix":"10.1093","volume":"163","author":[{"given":"Faizan","family":"Malik","sequence":"first","affiliation":[{"name":"Department of Pathology, St Jude Children\u2019s Research Hospital , Memphis, TN ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad K","family":"Eldomery","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Jude Children\u2019s Research Hospital , Memphis, TN ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, MD Anderson Cancer Center , Houston, TX ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Jude Children\u2019s Research Hospital , Memphis, TN ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Khanlari","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Jude Children\u2019s Research Hospital , Memphis, TN ,","place":["US"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"issue":"1","key":"2025031001324041500_CIT0001","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5858\/arpa.2020-0773-RA","article-title":"Small round cell tumors of soft tissue and bone","volume":"146","author":"Wei","year":"2021","journal-title":"Arch Pathol Lab Med."},{"issue":"7","key":"2025031001324041500_CIT0002","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic Neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia."},{"issue":"5","key":"2025031001324041500_CIT0003","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1046\/j.1365-2559.1999.00651.x","article-title":"Extra-medullary myeloid tumour (granulocytic sarcoma) is often misdiagnosed: a study of 26 cases","volume":"34","author":"Menasce","year":"1999","journal-title":"Histopathology."},{"issue":"2","key":"2025031001324041500_CIT0004","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1309\/AJCPO58YWIBUBESX","article-title":"Extramedullary manifestations of myeloid neoplasms","volume":"144","author":"Wilson","year":"2015","journal-title":"Am J Clin Pathol."},{"issue":"2","key":"2025031001324041500_CIT0005","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/sj.leu.2404491","article-title":"Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients","volume":"21","author":"Pileri","year":"2007","journal-title":"Leukemia."},{"issue":"9","key":"2025031001324041500_CIT0006","first-page":"790","article-title":"Extramedullary myeloid cell tumors. 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