{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:06:18Z","timestamp":1766088378154,"version":"3.41.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HD087221"],"award-info":[{"award-number":["U01 HD087221"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD089714","HD100015"],"award-info":[{"award-number":["HD089714","HD100015"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Before the Amsterdam Placental Workshop Group Consensus Statement, standardization in placental pathology assessment did not exist. This study evaluated the Amsterdam criteria\u2019s utility in correlating ischemic placental disease (IPD) with placental pathologic lesions in a cohort of largely unsubmitted term placentas with favorable outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this prospective case-controlled study at a single institution, all placentas were examined using Amsterdam protocols for gross sampling and microscopic review by 2 reviewers who were blinded to clinical history. Pathologic findings including hypoxic and chronic villitis of unknown etiology (VUE) scores were correlated with IPD status and whether the placenta was submitted to pathology using either a \u03c7\u00b2 test or Fisher exact test, as appropriate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 172 placentas collected between 2017 and 2020 were included. Approximately 18.6% (n = 32) were in the IPD group, and 81.4% (n = 140) were in the non-IPD group. No statistically significant differences in microscopic findings were seen in ascending infection, maternal vascular malperfusion, fetal vascular malperfusion, or VUE between groups or by submission status. When tabulated as a hypoxic score, placentas from the IPD group were associated with greater hypoxic scores compared to non-IPD placentas (P = .011). A positive association was observed between greater VUE scores and hypoxic scores (P = .007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In largely unsubmitted term placentas, the microscopic findings per Amsterdam criteria may be nonspecific. When tabulated as hypoxic or VUE scores, however, some clinicopathologic correlation may be seen in the setting of IPD. Further work is needed to refine the thresholds of meaningful reporting of placental pathology using the Amsterdam criteria.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqae174","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T18:16:53Z","timestamp":1736187413000},"page":"688-695","source":"Crossref","is-referenced-by-count":1,"title":["Does Amsterdam criteria applied to largely unsubmitted term placentas with favorable fetal outcomes show significant maternal clinicopathologic correlation?"],"prefix":"10.1093","volume":"163","author":[{"given":"Precious Ann","family":"Fortes","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Janzen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida Y Y","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sitaram","family":"Vangala","sequence":"additional","affiliation":[{"name":"Department of Medicine, Statistics Core, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyunghyun","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin U","family":"Devaskar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy S","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA , Los Angeles, CA ,","place":["US"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"2025052712483963500_CIT0001","doi-asserted-by":"publisher","first-page":"309","DOI":"10.2147\/IJWH.S45095","article-title":"Pathologic examination of the placenta: recommended vs observed practice in a university hospital","volume":"5","author":"Sills","year":"2013","journal-title":"Int J Womens Health"},{"issue":"7","key":"2025052712483963500_CIT0002","doi-asserted-by":"publisher","first-page":"698","DOI":"10.5858\/arpa.2015-0225-CC","article-title":"Sampling and definitions of placental lesions: Amsterdam Placental Workshop Group consensus statement","volume":"140","author":"Khong","year":"2016","journal-title":"Arch Pathol Lab Med."},{"issue":"suppl A","key":"2025052712483963500_CIT0003","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1016\/j.placenta.2007.09.003","article-title":"Placental pathology: a systematic approach with clinical correlations","volume":"29","author":"Redline","year":"2008","journal-title":"Placenta."},{"issue":"S 01","key":"2025052712483963500_CIT0004","doi-asserted-by":"publisher","first-page":"e853","DOI":"10.1055\/a-1961-2059","article-title":"A description of the imaging innovations for placental assessment in response to environmental pollution Study","volume":"41","author":"Janzen","year":"2024","journal-title":"Am J Perinatol."},{"key":"2025052712483963500_CIT0005","first-page":"1P","article-title":"Normative values for placental weights (N = 15463) [Abstract]","volume":"12","author":"Boyd","year":"1999","journal-title":"Mod Pathol."},{"volume-title":"Diagnostic Pathology: Placenta.","year":"2015","author":"Heerema-McKenney","key":"2025052712483963500_CIT0006"},{"issue":"6","key":"2025052712483963500_CIT0007","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1515\/jpm-2018-0055","article-title":"The frequency and type of placental histologic lesions in term pregnancies with normal outcome","volume":"46","author":"Romero","year":"2018","journal-title":"J Perinat Med."},{"key":"2025052712483963500_CIT0008","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.placenta.2022.09.007","article-title":"Cumulative effect of maternal vascular malperfusion types in the placenta on adverse pregnancy outcomes","volume":"129","author":"Arts","year":"2022","journal-title":"Placenta."},{"issue":"5","key":"2025052712483963500_CIT0009","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1097\/AOG.0000000000002264","article-title":"Maternal vascular malperfusion and adverse perinatal outcomes in low-risk nulliparous women","volume":"130","author":"Wright","year":"2017","journal-title":"Obstet Gynecol."},{"issue":"6","key":"2025052712483963500_CIT0010","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00428-011-1157-z","article-title":"Frequency and clinical significance of placental histological lesions in an unselected population at or near term","volume":"459","author":"Pathak","year":"2011","journal-title":"Virchows Arch."},{"issue":"6","key":"2025052712483963500_CIT0011","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/s41379-021-00747-4","article-title":"Four major patterns of placental injury: a stepwise guide for understanding and implementing the 2016 Amsterdam consensus","volume":"34","author":"Redline","year":"2021","journal-title":"Mod Pathol."},{"issue":"3","key":"2025052712483963500_CIT0012","doi-asserted-by":"publisher","first-page":"e31819","DOI":"10.1371\/journal.pone.0031819","article-title":"Acute histologic chorioamnionitis at term: nearly always noninfectious","volume":"7","author":"Roberts","year":"2012","journal-title":"PLoS One."},{"issue":"9","key":"2025052712483963500_CIT0013","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.placenta.2010.06.013","article-title":"Histologic chorioamnionitis is more common after spontaneous labor than after induced labor at term","volume":"31","author":"Park","year":"2010","journal-title":"Placenta."},{"key":"2025052712483963500_CIT0014","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.ejogrb.2015.02.034","article-title":"Term histologic chorioamnionitis: a heterogeneous condition","volume":"188","author":"Conti","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"issue":"4","key":"2025052712483963500_CIT0015","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1177\/1093526620904801","article-title":"Predictors of high grade and other clinically significant placental findings by indication for submission in singleton placentas from term births","volume":"23","author":"Zhou","year":"2020","journal-title":"Pediatr Dev Pathol."},{"issue":"6","key":"2025052712483963500_CIT0016","doi-asserted-by":"publisher","first-page":"604.e1","DOI":"10.1016\/j.ajog.2018.09.036","article-title":"The clinical heterogeneity of preeclampsia is related to both placental gene expression and placental histopathology","volume":"219","author":"Benton","year":"2018","journal-title":"Am J Obstet Gynecol."},{"issue":"S 01","key":"2025052712483963500_CIT0017","doi-asserted-by":"publisher","first-page":"e3351","DOI":"10.1055\/a-2223-3348","article-title":"Maternal factors and placental pathologies associated with a diagnosis of chronic villitis","volume":"41","author":"Rose","year":"2024","journal-title":"Am J Perinatol."},{"issue":"suppl A","key":"2025052712483963500_CIT0018","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1016\/j.placenta.2008.11.020","article-title":"Gabor Than Award Lecture 2008: pre-eclampsia\u2014from placental oxidative stress to maternal endothelial dysfunction","volume":"30","author":"Cindrova-Davies","year":"2009","journal-title":"Placenta."},{"issue":"5","key":"2025052712483963500_CIT0019","first-page":"449","article-title":"Practice guideline for examination of the placenta: developed by the Placental Pathology Practice Guideline Development Task Force of the College of American Pathologists","volume":"121","author":"Langston","year":"1997","journal-title":"Arch Pathol Lab Med."},{"key":"2025052712483963500_CIT0020","article-title":"Tissue pathway for histopathological examination of the placenta","author":"Evans","year":"2022","journal-title":"Royal College of Pathologists. Unique document number G108, version 3"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/163\/5\/688\/61355798\/aqae174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/163\/5\/688\/61355798\/aqae174.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:48:46Z","timestamp":1748364526000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/163\/5\/688\/7943535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,1,6]]},"published-print":{"date-parts":[[2025,5,17]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqae174","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"type":"print","value":"0002-9173"},{"type":"electronic","value":"1943-7722"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,1,6]]}}}