{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:22:00Z","timestamp":1793330520964,"version":"4.5.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To summarize the conclusions of the 2023 Society for Hematopathology\/European Association for Haematopathology workshop regarding Epstein-Barr virus (EBV)\u2013positive T- and natural killer (NK)\u2013cell lymphoproliferative disorders (LPDs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>There were 38 cases submitted to session 3 of the workshop.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cases included extranodal NK\/T-cell lymphoma (ENKTCL), nasal type (n\u2005=\u200516), EBV+ T- and NK-cell LPDs in children (n\u2005=\u200512), primary nodal EBV+ T- and NK-cell lymphoma (n\u2005=\u20055), and other EBV+ T- and NK-cell LPDs (n\u2005=\u20055). The ENKTCL cases highlighted some unusual features like indolent behavior, small cell morphology, and T-cell phenotype, including cases with CD4 and CD30 expression. The differential diagnosis of ENKTCL was illustrated by 4 cases with other primary cutaneous lymphomas. The difficulty in the diagnosis of systemic chronic active EBV disease, its complications, and the sometimes elusive boundaries among the EBV+ LPDs in children are also discussed. The submitted cases also unveiled cases of EBV+ \u03b3\u03b4 T-cell leukemia\/lymphoma not recognized under current classifications and cases of EBV+ CD8+ cytotoxic lymphomas associated with treatment for B-cell lymphomas. The need to have a low threshold to investigate the presence of EBV is highlighted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The diagnosis of EBV+ T- and NK-cell LPDs is complex and requires a multiparameter approach incorporating clinical information and morphologic and molecular features.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf020","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T20:01:39Z","timestamp":1751832099000},"page":"46-64","source":"Crossref","is-referenced-by-count":6,"title":["Epstein-Barr virus\u2013positive T- and NK-cell lymphoproliferative disorders: Report from the 2023 SH\/EA4HP Lymphoma Workshop"],"prefix":"10.1093","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5365","authenticated-orcid":false,"given":"Leticia","family":"Quintanilla-Martinez","sequence":"first","affiliation":[{"name":"Institute of Pathology and Neuropathology, University Hospital Tuebingen and Comprehensive Cancer Center , Tuebingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, The University of Texas, MD Anderson Cancer Center , Houston, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Chadburn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine , New York, NY ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"2025071122464015900_CIT0001","doi-asserted-by":"publisher","first-page":"e2328","DOI":"10.1002\/rmv.2328","article-title":"EBV associated T- and NK-cell lymphoproliferative diseases: a comprehensive overview of clinical manifestations and novel therapeutic insights","volume":"32","author":"Shafiee","year":"2022","journal-title":"Rev Med Virol."},{"key":"2025071122464015900_CIT0002","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.3390\/cancers13061414","article-title":"EBV and the pathogenesis of NK\/T cell lymphoma","volume":"13","author":"Montes-Mojarro","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2025071122464015900_CIT0003","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/CCO.0000000000000889","article-title":"EBV-associated NK and T-cell lymphoid 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