{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:30:44Z","timestamp":1784140244657,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA279965"],"award-info":[{"award-number":["R01CA279965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA279965"],"award-info":[{"award-number":["R01CA279965"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Endoscopic ultrasound (EUS)\u2013guided, fine-needle core biopsy (FNB), and through-the-needle microforceps biopsy (TTNB) are latest tools for evaluating pancreatic lesions. We aim to provide subspecialty surgical pathologists\u2019 experience with EUS-FNB\/TTNB in diagnosing pancreatic lesions at a large academic center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A 3-year review identified 101 EUS pancreatic specimens submitted for surgical pathology: 87 biopsy specimens (FNB\u2005=\u200558, TTNB\u2005=\u200529) and 14 fine-needle aspirations (FNAs). Diagnoses were compared with cytology and resection specimens when available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 101 cases, 10 had previous EUS-FNA cytology with inconclusive diagnoses. Rebiopsy with EUS-FNB\/TTNB provided definitive diagnoses in 9 cases. Thirty-five cases (18 cystic and 17 solid lesions) had concurrent surgical pathology and cytology specimens. The diagnostic yield of EUS-FNB\/TTNB biopsy specimens (69%) was significantly higher than that of cytology specimens (26%, P\u2005=\u2005.0017), as was the diagnostic accuracy (P\u2005=\u2005.0012). This diagnostic advantage was statistically significant in cystic lesions (FNB\/TTNB [83.3%] vs cytology [16.7%] for achieving a specific diagnosis, P\u2005=\u2005.0002) but not in solid lesions (61.5% vs 46.2%, P\u2005=\u2005.6951). Only in 1 case did cytology (adenocarcinoma) provide a more definitive diagnosis than surgical pathology (high-grade dysplasia cannot exclude adenocarcinoma).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The EUS-FNB\/TTNB methods complement EUS-FNA cytology in diagnosing pancreatic lesions, and they often outperforms concurrent cytology specimens, particularly in cystic lesions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf050","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T06:44:49Z","timestamp":1745477089000},"page":"351-359","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic ultrasound\u2013guided pancreatic core-needle\/microforceps biopsy is a valuable diagnostic tool for pancreatic lesions: Experience from a large academic institution"],"prefix":"10.1093","volume":"164","author":[{"given":"Saba","family":"Shafi","sequence":"first","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy L","family":"Frankel","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1325-1696","authenticated-orcid":false,"given":"Zaibo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somashekar G","family":"Krishna","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini K","family":"Esnakula","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Yearsley","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ohio State University Wexner Medical Center , Columbus, OH ,","place":["United 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