{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T22:10:39Z","timestamp":1757628639937,"version":"3.44.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Immune receptor translocation-associated 1 (IRTA1) expression, which has recently been shown to be highly specific for marginal zone lymphoma, is found in only a subset of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In this study, we examined whether IRTA1 expression in MALT lymphoma was dependent on anatomic location.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>IRTA1 immunohistochemistry was performed in 60 cases of extranodal MALT lymphoma, arising at breast, conjunctiva, lung, salivary gland, skin, and stomach (10 cases each). Expression was also scored with respect to detailed morphologic features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>IRTA1 staining was identified in 25 (42%) cases, ranging from 9 (90%) of 10 in lung to 2 (20%) of 10 in gastric MALT lymphoma. IRTA1 staining was not characteristic of specific morphologic features, as it was absent in most lymphoepithelial lesions, perifollicular cells, cells with overt monocytoid cytology, and plasmacytic cells. IRTA1 expression was also identified in 5 (50%) of 10 cases of pulmonary nodular lymphoid hyperplasia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>IRTA1 expression is heterogeneous in extranodal MALT lymphoma. Staining for IRTA1 is not characteristic of specific morphologic features, but varies with the anatomic site of disease. Knowledge of site-specific differences in MALT lymphomas will facilitate diagnosis in routine clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf056","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:47:36Z","timestamp":1747036056000},"page":"278-282","source":"Crossref","is-referenced-by-count":0,"title":["IRTA1 expression in extranodal marginal zone (MALT) lymphoma is variable across anatomic sites"],"prefix":"10.1093","volume":"164","author":[{"given":"Narendra","family":"Bhattarai","sequence":"first","affiliation":[{"name":"Rochester General Hospital , Rochester, NY ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-8085","authenticated-orcid":false,"given":"James R","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Cleveland Clinic , Cleveland, OH ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"2025091004264413800_CIT0001","first-page":"409","article-title":"Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT Lymphoma)","volume-title":"The International Consensus Classification of Myeloid and Lymphoid Neoplasms","author":"Gibson","year":"2025"},{"key":"2025091004264413800_CIT0002","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/hon.3152","article-title":"Marginal zone lymphomas","volume":"41","author":"Zucca","year":"2023","journal-title":"Hematol Oncol."},{"key":"2025091004264413800_CIT0003","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1056\/NEJMra2102568","article-title":"Marginal-zone lymphomas","volume":"386","author":"Rossi","year":"2022","journal-title":"N Engl J 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lymphomas","volume":"61","author":"Falini","year":"2012","journal-title":"Histopathology."},{"key":"2025091004264413800_CIT0007","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1097\/PAS.0000000000002005","article-title":"The distinctive nature of thyroid MALT lymphomas including IRTA1 expression","volume":"47","author":"Carlsen","year":"2023","journal-title":"Am J Surg Pathol."},{"key":"2025091004264413800_CIT0008","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/cup.14111","article-title":"IRTA1 positivity helps identify a MALT-lymphoma-like subset of primary cutaneous marginal zone lymphomas, largely but not exclusively defined by IgM expression","volume":"49","author":"Carlsen","year":"2022","journal-title":"J Cutan Pathol."},{"key":"2025091004264413800_CIT0009","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/ajcp\/aqy144","article-title":"IRTA1 and MNDA expression in marginal zone lymphoma: utility in differential diagnosis and implications for classification","volume":"151","author":"Wang","year":"2019","journal-title":"Am J Clin Pathol."},{"key":"2025091004264413800_CIT0010","first-page":"S133","article-title":"Are there site-specific differences among the MALT lymphomas\u2014morphologic, clinical","volume":"111","author":"Burke","year":"1999","journal-title":"Am J Clin Pathol."},{"key":"2025091004264413800_CIT0011","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1182\/blood-2015-12-624304","article-title":"The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance","volume":"127","author":"Zucca","year":"2016","journal-title":"Blood."},{"key":"2025091004264413800_CIT0012","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000496380","article-title":"Extranodal marginal-zone lymphomas: an entity with significant heterogeneity at different anatomic sites","volume":"142","author":"Kalpadakis","year":"2019","journal-title":"Acta Haematol."},{"key":"2025091004264413800_CIT0013","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.3324\/haematol.2011.040402","article-title":"Genomic profiles of MALT lymphomas: variability across anatomical sites","volume":"96","author":"Kwee","year":"2011","journal-title":"Haematologica."},{"key":"2025091004264413800_CIT0014","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s1074-7613(01)00109-1","article-title":"IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy","volume":"14","author":"Hatzivassiliou","year":"2001","journal-title":"Immunity."},{"key":"2025091004264413800_CIT0015","doi-asserted-by":"publisher","first-page":"3684","DOI":"10.1182\/blood-2003-03-0750","article-title":"Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)","volume":"102","author":"Falini","year":"2003","journal-title":"Blood."},{"key":"2025091004264413800_CIT0016","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.humpath.2016.09.011","article-title":"Immunohistochemical analysis of the novel marginal zone B-cell marker IRTA1 in malignant lymphoma","volume":"59","author":"Ikeda","year":"2017","journal-title":"Hum Pathol."}],"container-title":["American Journal of Clinical 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