{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T22:08:33Z","timestamp":1757628513571,"version":"3.44.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Rare large B-cell lymphomas (LBCLs) present with concurrent or subsequent lymphomatous effusion (solid-effusion LBCL, SE-LBCL), which may have an inferior prognosis compared with their noneffusion counterpart. In addition, the relationship between SE-LBCL and human herpesvirus 8\u2013negative effusion-based LBCL (EB-LBCL) remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We collected 141 cases of SE-LBCL and a control cohort of 101 cases of stage IV solid-only LBCL. The clinicopathologic features were analyzed and compared between SE-LBCL and solid-only LBCL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with SE-LBCL had a median age of 67 years with a male-to-female ratio of 1.3:1. Eighty-six patients had concurrent solid lymphoma and lymphomatous effusion, whereas 55 developed lymphomatous effusion subsequently. Most cases involved the pleural cavities (79%, 112\/141), followed by the peritoneal (21%, 29\/141) and pericardial (11%, 16\/141) cavities. BCL6, CD10, and MUM1 were expressed in 77% (90\/117), 46% (60\/130), and 61% (58\/95) of cases, respectively, and 58% (71\/123) were subclassified into the germinal center B-cell (GCB) subtype. Rearrangements of BCL2, BCL6, and MYC were detected in 42% (31\/73), 35% (22\/63), and 40% (35\/88), respectively, and 22% (19\/87) had both MYC and BCL2 rearrangements. The patients with SE-LBCL had a dismal prognosis, with a median survival of 5.7 months, which was significantly worse than solid-only LBCL (147.5 months; P\u2005&amp;lt;\u2005.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The pathologic features of SE-LBCL were similar to those of solid-only LBCL but distinct from those of EB-LBCL; in particular, lymphomatous effusion was an independently adverse prognostic factor in LBCL. Our study underscores the need for surveillance of lymphomatous effusion during LBCL staging and development of effective therapeutic regimens for SE-LBCL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf057","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:19:04Z","timestamp":1746778744000},"page":"390-401","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent or subsequent lymphomatous effusion in large B-cell lymphoma portends a dismal prognosis: A multi-institutional study"],"prefix":"10.1093","volume":"164","author":[{"given":"Savanah D","family":"Gisriel","sequence":"first","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT ,","place":["United States"]},{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin\u2013Madison , Madison, WI ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mayo Clinic , Rochester, MN ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-349X","authenticated-orcid":false,"given":"Haiming","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, MD Anderson Cancer Center , Houston, TX ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, MD Anderson Cancer Center , Houston, TX ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, MD Anderson Cancer Center , Houston, TX ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center , Durham, NC ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"ARUP Laboratories and Department of Pathology, University of Utah School of Medicine , Salt Lake City, UT ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan C","family":"Braunberger","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of New Mexico , Albuquerque, NM ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijun Y","family":"Xu-Monette","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center , Durham, NC ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins School of Medicine , Baltimore, MD ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-6336","authenticated-orcid":false,"given":"Endi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center , Durham, NC ,","place":["United States"]},{"name":"Department of Pathology, University of Southern California , Los Angeles, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian-Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of New Mexico , Albuquerque, NM ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorinda A","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Pathology, City of Hope National Medical Center , Duarte, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-8568","authenticated-orcid":false,"given":"Samuel G","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7287-2842","authenticated-orcid":false,"given":"Jing Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Colorado School of Medicine , Aurora, CO ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana P","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken H","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center , Durham, NC ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina L","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-3356","authenticated-orcid":false,"given":"Zenggang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University School of Medicine , New Haven, CT ,","place":["United States"]},{"name":"Department of Pathology, University of Colorado School of Medicine , Aurora, CO ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"2025091004265446000_CIT0001","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1038\/s41379-022-01091-x","article-title":"Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics","volume":"35","author":"Gisriel","year":"2022","journal-title":"Mod Pathol."},{"key":"2025091004265446000_CIT0002","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia."},{"key":"2025091004265446000_CIT0003","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1182\/blood.2022015851","article-title":"The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee","volume":"140","author":"Campo","year":"2022","journal-title":"Blood."},{"key":"2025091004265446000_CIT0004","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.arbres.2013.11.007","article-title":"Etiology of pleural effusions: analysis of more than 3,000 consecutive thoracenteses","volume":"50","author":"Porcel","year":"2014","journal-title":"Arch Bronconeumol."},{"key":"2025091004265446000_CIT0005","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1309\/AJCP6LXA2LKFZAMC","article-title":"Malignant effusions correlate with poorer prognosis in patients with diffuse large B-cell lymphoma","volume":"143","author":"Chen","year":"2015","journal-title":"Am J Clin Pathol."},{"key":"2025091004265446000_CIT0006","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/bjh.15431","article-title":"Pleural effusion at diagnosis predicts extremely poor outcomes in patients with diffuse large B-cell lymphoma harbouring MYC rearrangement","volume":"185","author":"Nitta","year":"2019","journal-title":"Br J Haematol."},{"key":"2025091004265446000_CIT0007","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00408-018-0182-y","article-title":"Pleural effusions in diffuse large B-cell lymphoma: clinical and prognostic significance","volume":"197","author":"Porcel","year":"2019","journal-title":"Lung."},{"key":"2025091004265446000_CIT0008","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood."},{"key":"2025091004265446000_CIT0009","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1200\/JCO.2011.41.0985","article-title":"Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone","volume":"30","author":"Johnson","year":"2012","journal-title":"J Clin Oncol."},{"key":"2025091004265446000_CIT0010","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s40364-021-00330-8","article-title":"Deciphering genes associated with diffuse large B-cell lymphoma with lymphomatous effusions: a mutational accumulation scoring approach","volume":"9","author":"Abdollahi","year":"2021","journal-title":"Biomark Res"},{"key":"2025091004265446000_CIT0011","doi-asserted-by":"publisher","first-page":"4442","DOI":"10.1182\/bloodadvances.2020002293","article-title":"Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis","volume":"4","author":"Kaji","year":"2020","journal-title":"Blood Adv."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/164\/3\/390\/63617084\/aqaf057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/164\/3\/390\/63617084\/aqaf057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T08:26:56Z","timestamp":1757492816000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/164\/3\/390\/8177277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,29]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6,29]]},"published-print":{"date-parts":[[2025,9,9]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqaf057","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"type":"print","value":"0002-9173"},{"type":"electronic","value":"1943-7722"}],"subject":[],"published-other":{"date-parts":[[2025,9]]},"published":{"date-parts":[[2025,6,29]]}}}