{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:32:12Z","timestamp":1790875932244,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We examined the utility of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry (IHC) in distinguishing breast angiosarcoma from benign or atypical vascular lesions (AVLs) of the breast.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>There were 26 breast angiosarcomas (24 radiation related and 2 primary), 6 radiation-related AVLs of the breast, and 16 other benign vascular lesions of the breast retrieved from our institutional archive and stained with PRAME IHC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-four of 26 (92%) breast angiosarcomas were positive for PRAME with moderate to strong staining intensities (median HScore, 255 [range, 90-300]), while 0 of 22 benign or atypical vascular lesions of the breast were PRAME positive (sensitivity, 92.3% [95% CI, 75.9%-98.6%]; specificity, 100% [95% CI, 85.1%-100%]); c-MYC was positive in all angiosarcoma cases but showed weak staining in several cases (median HScore, 155 [range, 30-280]). PRAME was negative in 1 of 2 primary angiosarcomas and negative in only 1 of 24 secondary angiosarcomas of the breast. None of the benign or atypical vascular lesions was stained with PRAME.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>It appears that PRAME expression occurs in a high proportion of radiation-related angiosarcomas and not in benign breast vascular lesions or AVLs. PRAME IHC is diagnostically useful in distinguishing benign from malignant vascular proliferations in patients with a history of radiation to the breast.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf084","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T14:18:43Z","timestamp":1756217923000},"page":"600-607","source":"Crossref","is-referenced-by-count":2,"title":["PRAME immunohistochemistry distinguishes breast secondary angiosarcoma from benign and atypical vascular lesions of the breast"],"prefix":"10.1093","volume":"164","author":[{"given":"Haley N","family":"Corbin","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azfar","family":"Neyaz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri E","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]},{"name":"Division of Breast, GYN, and Perinatal Pathology, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-8294","authenticated-orcid":false,"given":"Beth Z","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]},{"name":"Division of Breast, GYN, and Perinatal Pathology, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-6226","authenticated-orcid":false,"given":"Jing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]},{"name":"Division of Breast, GYN, and Perinatal Pathology, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-8014","authenticated-orcid":false,"given":"Jeffrey L","family":"Fine","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine , Pittsburgh, PA ,","place":["United States"]},{"name":"Division of Breast, GYN, and Perinatal Pathology, UPMC Magee-Womens Hospital , Pittsburgh, PA ,","place":["United 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