{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:36:38Z","timestamp":1792816598886,"version":"4.5.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hologic, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we compared the workflow of the Genius Digital Diagnostics System (Hologic, Inc) with our current workflow based on the ThinPrep Imaging System (Hologic, Inc) to assess potential efficiencies associated with digitalization of Papanicolaou screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Each step of the current workflow (glass slide movement and slide review) and the experimental workflow were documented. Substantial workflow efficiencies were associated with the reduction of glass slide movement observed with the experimental workflow of the Genius system compared with the ThinPrep system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ThinPrep-based workflow required more than 5 hours of hands-on time at specific synchronized times throughout the day, whereas the hands-on time of the experimental Genius Digital Diagnostics System was just over an hour and allowed glass movement at flexible times. In addition to these workflow efficiencies, the Genius Digital Diagnostics System resulted in much shorter review times (70.1 seconds) than the ThinPrep Imaging system (138.0 seconds) while maintaining similar agreement to the sign-out diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrated that implementing a Genius Dx-based workflow may result in substantial efficiency gains, which can mitigate workforce shortages and improve turnaround time without compromising screening accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf099","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:47:38Z","timestamp":1756381658000},"page":"746-751","source":"Crossref","is-referenced-by-count":7,"title":["Impact of the Genius Digital Diagnostics System on workflow and accuracy compared with the ThinPrep Imaging System for review of ThinPrep Papanicolaou tests"],"prefix":"10.1093","volume":"164","author":[{"given":"Kathleen M","family":"Murphy","sequence":"first","affiliation":[{"name":"ProPath, A Sonic Healthcare Anatomic Pathology Practice , Dallas, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Weatherhead","sequence":"additional","affiliation":[{"name":"ProPath, A Sonic Healthcare Anatomic Pathology Practice , Dallas, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Chenault","sequence":"additional","affiliation":[{"name":"ProPath, A Sonic Healthcare Anatomic Pathology Practice , Dallas, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"ProPath, A Sonic Healthcare Anatomic Pathology Practice , Dallas, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Sefcik","sequence":"additional","affiliation":[{"name":"ProPath, A Sonic Healthcare Anatomic Pathology Practice , Dallas, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Harrington","sequence":"additional","affiliation":[{"name":"Scientific Affairs Department, Hologic, Inc , Marlborough, MA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasey","family":"Johnson","sequence":"additional","affiliation":[{"name":"Scientific Affairs Department, Hologic, Inc , Marlborough, MA ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lemeshev","sequence":"additional","affiliation":[{"name":"ProPath, A Sonic Healthcare Anatomic Pathology Practice , Dallas, TX ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"2025111922463834100_CIT0001","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ygyno.2019.04.004","article-title":"Pathway to the Papanicolaou smear: the development of cervical cytology in twentieth-century America and implications in the present day","volume":"154","author":"Swailes","year":"2019","journal-title":"Gynecol Oncol."},{"key":"2025111922463834100_CIT0002","first-page":"S2","article-title":"The impact of liquid-based cytology in decreasing the incidence of cervical cancer","volume":"4(suppl 1)","author":"Gibb","year":"2011","journal-title":"Rev Obstet Gynecol."},{"key":"2025111922463834100_CIT0003","volume-title":"ThinPrep Integrated Imager Operator\u2019s Manual","year":"2018"},{"key":"2025111922463834100_CIT0004","volume-title":"BD FocalPoint SlideProfiler. 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Instructions for Use","year":"2021"},{"key":"2025111922463834100_CIT0012","author":"Dhand","year":"2014"},{"key":"2025111922463834100_CIT0013","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/cncy.22695","article-title":"Comparison of the Hologic Genius Digital Diagnostics System with the ThinPrep Imaging System\u2014a retrospective assessment","volume":"131","author":"Ikenberg","year":"2023","journal-title":"Cancer Cytopathol"},{"key":"2025111922463834100_CIT0014","doi-asserted-by":"publisher","first-page":"100391","DOI":"10.1016\/j.jpi.2024.100391","article-title":"Validation of AI-assisted ThinPrep Pap test screening using the Genius Digital Diagnostics System","volume":"15","author":"Cantley","year":"2024","journal-title":"J Pathol Inform"},{"key":"2025111922463834100_CIT0015","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.patol.2024.03.005","article-title":"Validation of digital image slides for diagnosis in cervico-vaginal cytology","volume":"57","author":"Tresserra","year":"2024","journal-title":"Rev Esp Patol"},{"key":"2025111922463834100_CIT0016","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1159\/000326001","article-title":"Implementation and evaluation of a new automated interactive image analysis system","volume":"50","author":"Bolger","year":"2006","journal-title":"Acta Cytol."},{"key":"2025111922463834100_CIT0017","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1002\/dc.20640","article-title":"Automated screening versus manual screening: a comparison of the ThinPrep Imaging System and manual screening in a time study","volume":"35","author":"Schledermann","year":"2007","journal-title":"Diagn Cytopathol."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/164\/5\/746\/64378474\/aqaf099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ajcp\/article-pdf\/164\/5\/746\/64378474\/aqaf099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T03:46:46Z","timestamp":1763610406000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/164\/5\/746\/8263345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,25]]},"published-print":{"date-parts":[[2025,11,19]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqaf099","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11]]},"published":{"date-parts":[[2025,9,25]]}}}