{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:42:38Z","timestamp":1780926158273,"version":"3.54.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ningbo Top Medical and Health Research Program","award":["2023010211"],"award-info":[{"award-number":["2023010211"]}]},{"name":"Zhejiang Provincial Medicine and Health Research Foundation","award":["2023KY040"],"award-info":[{"award-number":["2023KY040"]}]},{"name":"Zhejiang Provincial Medicine and Health Research Foundation","award":["2024KY1584"],"award-info":[{"award-number":["2024KY1584"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the clinicopathologic, immunohistochemical, and molecular features of 2 new cases of xanthomatous giant cell renal cell carcinoma, a rare TSC2\/MTOR-altered renal neoplasm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Both tumors underwent histologic evaluation, immunohistochemical profiling, and DNA-based targeted next-generation sequencing. Fluorescence in situ hybridization for TFE3 rearrangement was performed in 1 case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both patients were men (aged 27 and 64 years) with incidentally detected renal masses showing infiltrative growth and discohesive large cells with a xanthomatous-eosinophilic cytoplasm, basophilic stippling, vacuolization, and prominent nucleoli. Both tumors were positive for PAX8, CD10, vimentin, and GPNMB; keratin 20 was diffusely strong in 1 patient and isolated in the other. One case showed TFE3 and Melan-A coexpression without TFE3 rearrangement. Biallelic TSC2 mutations were identified in both cases, corroborated by loss of TSC2 protein expression. Both patients were disease-free at 15 and 40\u2009months postsurgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Xanthomatous giant cell renal cell carcinoma represents a distinct morphologic variant of TSC\/MTOR-altered renal neoplasms with indolent behavior despite aggressive histologic features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqaf129","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:59:53Z","timestamp":1761393593000},"page":"953-959","source":"Crossref","is-referenced-by-count":1,"title":["Xanthomatous giant cell renal cell carcinoma: clinicopathologic and molecular characterization of 2 additional cases with biallelic\n                    <i>TSC2<\/i>\n                    mutations"],"prefix":"10.1093","volume":"164","author":[{"given":"Qiancheng","family":"Chen","sequence":"first","affiliation":[{"name":"Health Science Center, Ningbo University , Ningbo,","place":["China"]},{"name":"Ningbo Clinical Pathology Diagnosis Center , Ningbo,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli","family":"Wang","sequence":"additional","affiliation":[{"name":"Ningbo Clinical Pathology Diagnosis Center , Ningbo,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suying","family":"Wang","sequence":"additional","affiliation":[{"name":"Ningbo Clinical Pathology Diagnosis Center , Ningbo,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ningbo Clinical Pathology Diagnosis Center , 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