{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:12:44Z","timestamp":1787008364203,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Salivary gland aspirates classified as salivary gland neoplasm of uncertain malignant potential (SUMP) under the Milan System for Reporting Salivary Gland Cytopathology pose a diagnostic challenge due to their indeterminate cytologic features. We evaluate the utility of intraoperative frozen section in risk stratification and in guiding surgical management in SUMP cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 75 SUMP cases from 2019 to 2024 with paired frozen section and final pathology. Frozen section diagnoses, final pathology, and intraoperative decision-making processes were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Frozen section reclassified 89% (67\/75) of cases as benign or malignant, while 11% (8\/75) remained indeterminate. Excluding indeterminate cases, frozen section demonstrated a diagnostic accuracy of 96% (64\/67), with a sensitivity of 81% (13\/16) and a specificity of 100% (51\/51). Frozen section refined risk stratification by decreasing the baseline risk of malignancy from 23% before frozen section to 6% in benign frozen section cases. Malignant and indeterminate frozen section cases had risks of malignancy of 100% and 13%, respectively (\u03c72\u2009=\u200953.84, P\u2009&amp;lt;\u2009.001). The combination of intraoperative findings and frozen section results influenced surgical management: More extensive resections were performed in 15% (11\/75) of patients, whereas the remainder underwent conservative surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative frozen section substantially improves risk stratification and informs surgical management in SUMP, though persistent indeterminate cases underscore the need for enhanced preoperative diagnostic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqag009","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:36:03Z","timestamp":1768566963000},"source":"Crossref","is-referenced-by-count":1,"title":["Utility of intraoperative frozen section analysis in risk stratification and surgical decision-making for salivary gland neoplasms of uncertain malignant potential"],"prefix":"10.1093","volume":"165","author":[{"given":"Jaylou M","family":"Velez Torres","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesica G","family":"Miltos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-312X","authenticated-orcid":false,"given":"Youley","family":"Tjendra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-2428","authenticated-orcid":false,"given":"Carmen","family":"Gomez-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lora Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr N","family":"Kryvenko","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Desai Sethi Urology Institute, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]},{"name":"Department of Radiation Oncology, University of Miami Miller School of Medicine , Miami, FL,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"2026030521444499600_aqag009-B1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/j.1365-2303.1990.tb00360.x","article-title":"Fine needle aspiration cytology of salivary gland lesions: advantages and pitfalls","volume":"1","author":"Kocjan","year":"1990","journal-title":"Cytopathology"},{"key":"2026030521444499600_aqag009-B2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jasc.2023.08.004","article-title":"Second edition of the Milan System for Reporting Salivary Gland Cytopathology: refining the role of salivary gland FNA","volume":"13","author":"Rossi","year":"2024","journal-title":"J Am Soc 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