{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T12:40:56Z","timestamp":1776602456671,"version":"3.51.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to investigate the predictive value of S1PR3 for the 3-year cumulative incidence of relapse (CIR) in adult patients with B-cell acute lymphoblastic leukemia (B-ALL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled 285 adult patients with B-ALL and 13 healthy controls from January 2019 through January 2022. S1PR3 expression was analyzed in leukemia cell lines and peripheral blood mononuclear cells (MCs) using reverse transcription\u2013quantitative polymerase chain reaction (RT-qPCR) and Western blot. S1PR3 expression in bone marrow MCs was also measured by RT-qPCR. Predictive value was assessed using receiver operating characteristic curve analysis. Spearman correlation analysis was performed for correlation studies. Kaplan-Meier curves were employed for survival analysis. Cox regression was conducted for risk factor analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>S1PR3 was upregulated in leukemia cell lines and B-ALL patient MCs compared with controls (P\u2009&amp;lt;\u2009.001). Relapsed patients demonstrated elevated S1PR3 levels compared with nonrelapsed patients (P\u2009&amp;lt;\u2009.001). S1PR3 expression predicted B-ALL relapse with an area under the curve of 0.887. Patients with high S1PR3 had a significantly higher relapse rate than those with low S1PR3 (P\u2009&amp;lt;\u2009.001). S1PR3 expression was closely associated with clinicopathologic characteristics. High S1PR3 expression was associated with a leftward shift in Kaplan-Meier curves and significantly increased CIR in patients (P\u2009&amp;lt;\u2009.001). High S1PR3 expression was an independent risk factor for relapse within 3\u2009years in patients with B-ALL (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated S1PR3 expression is an independent predictor of relapse in adult B-ALL, providing a novel biomarker to enhance risk stratification and guide potential targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqag026","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:50:09Z","timestamp":1772283009000},"source":"Crossref","is-referenced-by-count":0,"title":["S1PR3 expression independently predicts the cumulative incidence of relapse in adult B-cell acute lymphoblastic leukemia: a single-center retrospective analysis"],"prefix":"10.1093","volume":"165","author":[{"given":"Lijun","family":"Hao","sequence":"first","affiliation":[{"name":"Clinical Laboratory Center, People\u2019s Hospital of Xinjiang Uygur Autonomous Region , Urumqi City, Xinjiang Uygur Autonomous Region,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng","family":"Xu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, People\u2019s Hospital of Xinjiang Uygur Autonomous Region , Urumqi City, Xinjiang Uygur Autonomous Region,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, People\u2019s Hospital of Xinjiang Uygur Autonomous Region , Urumqi City, Xinjiang Uygur Autonomous 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