{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T19:04:59Z","timestamp":1779563099366,"version":"3.53.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Yttrium-90 (90Y) is a radioactive isotope of yttrium used in transarterial radioembolization (also known as selective internal radiation therapy) of hepatocellular carcinoma and metastases to the liver. Although injury to the gastrointestinal tract due to escape of 90Y microspheres beyond the intended target neoplasm has been reported in the pathology literature, lung toxicity caused by 90Y microspheres has only rarely been documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 66-year-old woman with a history of ovarian serous carcinoma metastatic to the liver was treated with radioembolization of a liver metastasis with 90Y SIR-Spheres (Sirtex SIR-Spheres Pty Ltd) via the right hepatic artery. A few days later, she developed shortness of breath and was subsequently found to have bilateral evolving consolidations and ground-glass opacities on serial chest computed tomographic imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Transbronchial biopsy of the left lower lobe showed organizing acute lung injury along with rare eosinophils and 2 90Y microspheres. The patient was treated with corticosteroid therapy with significant clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first report of a case in which transbronchial lung biopsy led to diagnosis of 90Y-related radiation lung injury in a patient in whom this diagnosis was not previously suspected clinically or radiologically. We recommend adding 90Y to the list of etiologies of acute lung injury with eosinophils. Pathologists should familiarize themselves with the histologic appearance of 90Y microspheres because identification of these structures in the lung can be diagnostic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqag056","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:57:57Z","timestamp":1777377477000},"source":"Crossref","is-referenced-by-count":0,"title":["Radiation injury to the lung caused by yttrium-90 resin microspheres (SIR-Spheres) diagnosed by transbronchial lung biopsy"],"prefix":"10.1093","volume":"165","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9660-2599","authenticated-orcid":false,"given":"Sanjay","family":"Mukhopadhyay","sequence":"first","affiliation":[{"name":"Department of Pathology, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Section of Interventional Radiology, Diagnostics Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aamer","family":"Chughtai","sequence":"additional","affiliation":[{"name":"Section of Thoracic Imaging, Diagnostics Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Eltz Soares","sequence":"additional","affiliation":[{"name":"Section of Thoracic Imaging, Diagnostics Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabamita","family":"Bisen","sequence":"additional","affiliation":[{"name":"Section of Pulmonary Medicine, Integrated Hospital Care Institute, Cleveland Clinic , Cleveland, OH,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"2026052314532057200_aqag056-B1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/00000658-196508000-00018","article-title":"Treatment of inoperable primary pancreatic and liver cancer by the intra-arterial administration of radioactive isotopes (Y90 radiating microspheres)","volume":"162","author":"Ariel","year":"1965","journal-title":"Ann Surg"},{"key":"2026052314532057200_aqag056-B2","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1007\/s00259-021-05600-z","article-title":"EANM procedure guideline for the treatment of liver cancer and liver metastases with intra-arterial radioactive compounds","volume":"49","author":"Weber","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"suppl 2","key":"2026052314532057200_aqag056-B3","doi-asserted-by":"publisher","first-page":"104S","DOI":"10.2967\/jnumed.116.187229","article-title":"Radioembolization of colorectal liver metastases: indications, technique and outcomes","volume":"58","author":"Boas","year":"2017","journal-title":"J Nucl Med"},{"key":"2026052314532057200_aqag056-B4","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.jvir.2024.07.006","article-title":"Outcomes analysis of yttrium-90 radioembolization for tumors other than metastatic colorectal cancer from the Radiation-Emitting SIR-Spheres in Nonresectable (RESiN) registry","volume":"35","author":"Zhou","year":"2024","journal-title":"J Vasc Interv Radiol"},{"key":"2026052314532057200_aqag056-B5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1097\/PAS.0000000000001223","article-title":"90Y-TheraSpheres: the new look of yttrium-90","volume":"43","author":"Arnold","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"2026052314532057200_aqag056-B6","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1097\/PAS.0000000000001901","article-title":"Gastrointestinal tract injury by yttrium-90 appears largely restricted to resin microspheres but can occur years after embolization","volume":"46","author":"Feely","year":"2022","journal-title":"Am J Surg Pathol"},{"key":"2026052314532057200_aqag056-B7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jvir.2024.08.031","article-title":"Radiation pneumonitis after yttrium-90 radioembolization. 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