{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:01:40Z","timestamp":1790596900688,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The thromboelastography (TEG) 6s Global Hemostasis Cartridge package insert recommends a 15-minute incubation of citrated blood prior to testing; however, most centers run samples immediately. Limited data are available to evaluate how incubation affects results and thus influences hemostatic transfusion decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center prospective study, 35 adult surgical and critical care patients were enrolled. Paired citrated samples were tested immediately upon laboratory arrival vs after a 15-minute benchtop incubation at room temperature. Primary endpoints included changes in citrated kaolin\u2013reaction time (CK-R), kaolin with heparinase\u2013reaction time (CKH-R), citrated kaolin\u2013maximum amplitude (CK-MA), Citrated Rapid Thromboelastography Maximum Amplitude (CRT-MA), and citrated functional fibrinogen\u2013maximum amplitude (CFF-MA) (fibrin-fibrinogen contribution). Paired t tests were used for analysis, and percent differences were calculated as [(Incubated \u2013 Immediate) \/ Incubated]\u2009\u00d7\u2009100%. Categorical interpretation shifts (low\/normal\/high) were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A 15-minute incubation significantly shortened CK-R (8.5\u2009\u00b1\u20093.4 vs 7.4\u2009\u00b1\u20093.1\u2009minutes; P &amp;lt; .01) and CKH-R (7.2\u2009\u00b1\u20092.7 vs 6.9\u2009\u00b1\u20092.5\u2009minutes; P &amp;lt; .01), with mean percent changes of \u221217% and \u221212%, respectively. CK-MA decreased marginally (57.0\u2009\u00b1\u200916.0 vs 56.2\u2009\u00b1\u200912.4\u2009mm; P &amp;lt; .01), while CFF-MA remained unchanged (P\u2009=\u2009.976). Notably, 23% of CK-R results shifted interpretation categories after incubation, whereas no CFF-MA categories changed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A 15-minute incubation significantly shortens CK-R\/CKH-R and marginally decreases CK-MA, potentially normalizing hyper- or hypocoagulable readings. Omitting incubation risks misclassification and inappropriate plasma\/prothrombin complex concentrate administration. Strict adherence to the manufacturer\u2019s incubation protocol is recommended except in emergencies, and local transfusion algorithms should specify whether \u201cimmediate\u201d or \u201cincubated\u201d TEG cutoffs apply.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqag096","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:01:44Z","timestamp":1785585704000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of a 15-minute incubation on citrated TEG (thromboelastography) results in adult surgical patients\u2014a prospective observational study"],"prefix":"10.1093","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-3621","authenticated-orcid":false,"given":"Hong","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell Health , New Hyde Park, NY,","place":["United 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