{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:48:39Z","timestamp":1781531319040,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.1093\/ajcp\/aqx107","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T07:07:59Z","timestamp":1504076879000},"page":"8-16","source":"Crossref","is-referenced-by-count":20,"title":["Immunolocalization of CD163+ Tumor-Associated Macrophages and Symmetric Proliferation of Ki-67 as Biomarkers to Differentiate New Different Grades of Laryngeal Dysplasia"],"prefix":"10.1093","volume":"149","author":[{"given":"Caili","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"key\n\t\t\t\t20180125092146_CIT0001","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/modpathol.2011.50","article-title":"Interobserver variability of laryngeal mucosal premalignant lesions: a histopathological evaluation","volume":"24","year":"2011","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t20180125092146_CIT0002","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3109\/00016489.2016.1165862","article-title":"Droplet digital PCR and qRT-PCR to detect circulating mIR-21 in laryngeal squamous cell carcinoma and pre-malignant laryngeal lesions","volume":"136","year":"2016","journal-title":"Acta Otolaryngol"},{"key":"key\n\t\t\t\t20180125092146_CIT0003","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1758-3284-1-11","article-title":"Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility","volume":"1","year":"2009","journal-title":"Head Neck Oncol"},{"key":"key\n\t\t\t\t20180125092146_CIT0004","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/00016489.2011.642812","article-title":"Is severe dysplasia the same lesion as carcinoma in situ? 10-year follow-up of laryngeal precancerous lesions","volume":"132","year":"2012","journal-title":"Acta Otolaryngol"},{"key":"key\n\t\t\t\t20180125092146_CIT0005","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/his.12427","article-title":"Evaluation of a new grading system for laryngeal squamous intraepithelial lesions","volume":"65","year":"2014","journal-title":"Histopathology"},{"key":"key\n\t\t\t\t20180125092146_CIT0006","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s12105-017-0788-z","article-title":"Update from the 4th edition of the World Health Organization Classification of Head and Neck Tumours: what is new in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space","volume":"11","year":"2017","journal-title":"Head Neck Pathol"},{"key":"key\n\t\t\t\t20180125092146_CIT0007","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","article-title":"Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm","volume":"11","year":"2010","journal-title":"Nat Immunol"},{"key":"key\n\t\t\t\t20180125092146_CIT0008","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.taap.2014.07.001","article-title":"Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6","volume":"279","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"key\n\t\t\t\t20180125092146_CIT0009","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","year":"2002","journal-title":"Trends Immunol"},{"key":"key\n\t\t\t\t20180125092146_CIT0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.5732\/cjc.010.10336","article-title":"Clinical significance of tumor-associated macrophage infiltration in supraglottic laryngeal carcinoma","volume":"30","year":"2011","journal-title":"Chin J Cancer"},{"key":"key\n\t\t\t\t20180125092146_CIT0011","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1186\/s12885-015-1587-0","article-title":"Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a TH1-dominated microenvironment","volume":"15","year":"2015","journal-title":"BMC Cancer"},{"key":"key\n\t\t\t\t20180125092146_CIT0012","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1447-0756.2012.02036.x","article-title":"Tumor-associated macrophages correlate with progesterone receptor loss in endometrial endometrioid adenocarcinoma","volume":"39","year":"2013","journal-title":"J Obstet Gynaecol Res"},{"key":"key\n\t\t\t\t20180125092146_CIT0013","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/0972-124X.131315","article-title":"Immunolocalization of Ki-67 in different periodontal conditions","volume":"18","year":"2014","journal-title":"J Indian Soc Periodontol"},{"key":"key\n\t\t\t\t20180125092146_CIT0014","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1111\/jdv.13671","article-title":"Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression during malignant transformation of the lip epithelium","volume":"30","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key\n\t\t\t\t20180125092146_CIT0015","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S0022215100133924","article-title":"Expression of Ki-67 antigen and proliferative cell nuclear antigen in benign and malignant epithelial lesions of the larynx","volume":"110","year":"1996","journal-title":"J Laryngol Otol"},{"key":"key\n\t\t\t\t20180125092146_CIT0016","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/jid.2011.9","article-title":"Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated","volume":"131","year":"2011","journal-title":"J Invest Dermatol"},{"key":"key\n\t\t\t\t20180125092146_CIT0017","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1590\/S1807-59322011001100006","article-title":"M2-polarized tumor-associated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma","volume":"66","year":"2011","journal-title":"Clinics (Sao Paulo)"},{"key":"key\n\t\t\t\t20180125092146_CIT0018","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/jop.12164","article-title":"Asymmetrical proliferative pattern loss during malignant transformation of the oral mucosa","volume":"43","year":"2014","journal-title":"J Oral Pathol Med"},{"key":"key\n\t\t\t\t20180125092146_CIT0019","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000342396","article-title":"Immunohistochemical analysis of inflammatory cells in benign and precancerous lesions and carcinoma of the prostate","volume":"80","year":"2013","journal-title":"Pathobiology"},{"key":"key\n\t\t\t\t20180125092146_CIT0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2273.1994.tb01140.x","article-title":"Has the cellular proliferation marker Ki67 any clinical relevance in squamous cell carcinoma of the head and neck","volume":"19","year":"1994","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"key\n\t\t\t\t20180125092146_CIT0021","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tig.2008.10.012","article-title":"Co-evolution of tumor cells and their microenvironment","volume":"25","year":"2009","journal-title":"Trends Genet"},{"key":"key\n\t\t\t\t20180125092146_CIT0022","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","year":"2012","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20180125092146_CIT0023","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2009.11.008","article-title":"Transforming growth factor beta (TGF-beta) and inflammation in cancer","volume":"21","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"key":"key\n\t\t\t\t20180125092146_CIT0024","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccr.2006.11.023","article-title":"High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene","volume":"11","year":"2007","journal-title":"Cancer Cell"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/149\/1\/8\/23647936\/aqx107.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T19:08:15Z","timestamp":1570043295000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/ajcp\/article\/149\/1\/8\/4706014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,6]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12,6]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqx107","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2017,12,6]]}}}