{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T23:11:55Z","timestamp":1744499515122,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL007627"],"award-info":[{"award-number":["HL007627"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,7]]},"DOI":"10.1093\/ajcp\/aqy001","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T15:10:30Z","timestamp":1518448230000},"page":"300-309","source":"Crossref","is-referenced-by-count":9,"title":["Loss of Full-Length GATA1 Expression in Megakaryocytes Is a Sensitive and Specific Immunohistochemical Marker for the Diagnosis of Myeloid Proliferative Disorder Related to Down Syndrome"],"prefix":"10.1093","volume":"149","author":[{"given":"Winston Y","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga K","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"},{"name":"Department of Pathology, Boston Children\u2019s Hospital, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine S","family":"Pinkus","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"key\n\t\t\t\t20180625082815_CIT0001","first-page":"943","article-title":"The biology of pediatric acute megakaryoblastic leukemia","volume":"126","author":"Gruber","year":"2015","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0002","first-page":"3","article-title":"Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis","volume":"147","author":"Roy","year":"2009","journal-title":"Br J Haematol"},{"key":"key\n\t\t\t\t20180625082815_CIT0003","first-page":"2391","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0004","first-page":"126","article-title":"Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts","volume":"217","author":"Langebrake","year":"2005","journal-title":"Klin Padiatr"},{"key":"key\n\t\t\t\t20180625082815_CIT0005","first-page":"204","article-title":"Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome: an immunophenotypic analysis","volume":"116","author":"Karandikar","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"key\n\t\t\t\t20180625082815_CIT0006","first-page":"1302","article-title":"Transient abnormal myelopoiesis in neonates: GATA get the diagnosis","volume":"138","author":"Bombery","year":"2014","journal-title":"Arch Pathol Lab Med"},{"key":"key\n\t\t\t\t20180625082815_CIT0007","first-page":"2222","article-title":"Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia","volume":"118","author":"Alford","year":"2011","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0008","first-page":"3368","article-title":"Transcriptional regulation of erythropoiesis: an affair involving multiple partners","volume":"21","author":"Cantor","year":"2002","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180625082815_CIT0009","first-page":"993","article-title":"Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus","volume":"125","author":"Byrska-Bishop","year":"2015","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180625082815_CIT0010","first-page":"613","article-title":"Developmental stage-selective effect of somatically mutated leukemogenic transcription factor gata1","volume":"37","author":"Li","year":"2005","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180625082815_CIT0011","first-page":"988","article-title":"Perturbation of fetal hematopoiesis in a mouse model of Down syndrome\u2019s transient myeloproliferative disorder","volume":"122","author":"Birger","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0012","first-page":"1293","article-title":"The landscape of somatic mutations in Down syndrome\u2013related myeloid disorders","volume":"45","author":"Yoshida","year":"2013","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180625082815_CIT0013","first-page":"587","article-title":"Haematopoietic development and leukaemia in Down syndrome","volume":"167","author":"Roberts","year":"2014","journal-title":"Br J Haematol"},{"key":"key\n\t\t\t\t20180625082815_CIT0014","first-page":"1353","article-title":"GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome","volume":"29","author":"Pine","year":"2005","journal-title":"Leuk Res"},{"key":"key\n\t\t\t\t20180625082815_CIT0015","first-page":"420","article-title":"GATA1 is a sensitive and specific nuclear marker for erythroid and megakaryocytic lineages","volume":"147","author":"Lee","year":"2017","journal-title":"Am J Clin Pathol"},{"key":"key\n\t\t\t\t20180625082815_CIT0016","first-page":"148","article-title":"Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome","volume":"32","author":"Wechsler","year":"2002","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180625082815_CIT0017","first-page":"807","article-title":"An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis","volume":"38","author":"Hollanda","year":"2006","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180625082815_CIT0018","first-page":"2753","article-title":"Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome","volume":"114","author":"Cabelof","year":"2009","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0019","first-page":"2439","article-title":"Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia","volume":"122","author":"Sankaran","year":"2012","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180625082815_CIT0020","first-page":"554","article-title":"Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome","volume":"122","author":"Nikolaev","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0021","first-page":"2017","article-title":"Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models","volume":"209","author":"Thiollier","year":"2012","journal-title":"J Exp Med"},{"key":"key\n\t\t\t\t20180625082815_CIT0022","first-page":"3908","article-title":"GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia","volume":"122","author":"Roberts","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0023","first-page":"3181","article-title":"Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome","volume":"121","author":"Toki","year":"2013","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180625082815_CIT0024","first-page":"333","article-title":"Transient abnormal myelopoiesis and AML in Down syndrome: an update","volume":"11","author":"Bhatnagar","year":"2016","journal-title":"Curr Hematol Malig Rep"},{"key":"key\n\t\t\t\t20180625082815_CIT0025","first-page":"1228","article-title":"Systematic cellular disease models reveal synergistic interaction of trisomy 21 and GATA1 mutations in hematopoietic abnormalities","volume":"15","author":"Banno","year":"2016","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180625082815_CIT0026","first-page":"6136","article-title":"Down syndrome\u2013associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies","volume":"4","author":"Kazuki","year":"2014","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180625082815_CIT0027","first-page":"3242","article-title":"The gata1 mutation in an adult patient with acute megakaryoblastic leukemia not accompanying Down syndrome","volume":"103","author":"Harigae","year":"2004","journal-title":"Blood"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/149\/4\/300\/25082052\/aqy001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T08:29:38Z","timestamp":1529915378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/149\/4\/300\/4898185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,2,22]]},"published-print":{"date-parts":[[2018,3,7]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqy001","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"type":"print","value":"0002-9173"},{"type":"electronic","value":"1943-7722"}],"subject":[],"published-other":{"date-parts":[[2018,4]]},"published":{"date-parts":[[2018,2,22]]}}}