{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:55:10Z","timestamp":1790816110569,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,30]]},"DOI":"10.1093\/ajcp\/aqy061","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T19:09:51Z","timestamp":1526929791000},"page":"285-292","source":"Crossref","is-referenced-by-count":24,"title":["Estimate of the Prevalence of Anti-Gastric Parietal Cell Autoantibodies in Healthy Individuals Is Method Dependent"],"prefix":"10.1093","volume":"150","author":[{"given":"Marcello","family":"Bagnasco","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy"},{"name":"Laboratory of Autoimmunology, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-1116","authenticated-orcid":false,"given":"Daniele","family":"Saverino","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Sperimentale, University of Genoa, Genoa, Italy"},{"name":"Laboratory of Autoimmunology, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pupo","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy"},{"name":"Laboratory of Autoimmunology, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Marchiano","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy"},{"name":"Laboratory of Autoimmunology, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Alessio","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry, Papa Giovanni Hospital XXIII, Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schlumberger","sequence":"additional","affiliation":[{"name":"Institute for Experimental Immunology, Euroimmun, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Antico","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology, Civic Hospital, Santorso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaola","family":"Pesce","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy"},{"name":"Laboratory of Autoimmunology, Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Bizzaro","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"key\n\t\t\t\t20180830111349_CIT0001","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.beem.2004.11.004","article-title":"Non-thyroid autoantibodies in autoimmune thyroid disease","volume":"19","author":"Weetman","year":"2005","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20180830111349_CIT0002","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/08916939008998434","article-title":"Studies with recombinant autoepitopes of thyroid peroxidase: evidence suggesting an epitope shared between the thyroid and the gastric parietal cell","volume":"8","author":"Elisei","year":"1990","journal-title":"Autoimmunity"},{"key":"key\n\t\t\t\t20180830111349_CIT0003","first-page":"22","article-title":"The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes","volume":"1","author":"Lam-Tse","year":"2003","journal-title":"Pediatr Endocrinol Rev"},{"key":"key\n\t\t\t\t20180830111349_CIT0004","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1210\/edrv.23.3.0466","article-title":"Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction","volume":"23","author":"Betterle","year":"2002","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20180830111349_CIT0005","first-page":"376","article-title":"Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review","volume":"67","author":"Van den Driessche","year":"2009","journal-title":"Neth J Med"},{"key":"key\n\t\t\t\t20180830111349_CIT0006","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1046\/j.1365-2249.2001.01668.x","article-title":"Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes","volume":"126","author":"De Block","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20180830111349_CIT0007","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2337\/diacare.26.1.82","article-title":"Autoimmune gastropathy in type 1 diabetic patients with parietal cell antibodies: histological and clinical findings","volume":"26","author":"De Block","year":"2003","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180830111349_CIT0008","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/PAT.0b013e32835cc22c","article-title":"Autoimmune gastritis: novel clues to histological diagnosis","volume":"45","author":"Bettington","year":"2013","journal-title":"Pathology"},{"key":"key\n\t\t\t\t20180830111349_CIT0009","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/modpathol.3880499","article-title":"Autoimmune gastritis: distinct histological and immunohistochemical findings before complete loss of oxyntic glands","volume":"15","author":"Torbenson","year":"2002","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t20180830111349_CIT0010","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1097\/01.pas.0000213337.25111.37","article-title":"Atrophic autoimmune pangastritis: a distinctive form of antral and fundic gastritis associated with systemic autoimmune disease","volume":"30","author":"Jevremovic","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t20180830111349_CIT0011","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.autrev.2014.01.042","article-title":"Diagnosis and classification of pernicious anemia","volume":"13","author":"Bizzaro","year":"2014","journal-title":"Autoimmun Rev"},{"key":"key\n\t\t\t\t20180830111349_CIT0012","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrgastro.2013.101","article-title":"Autoimmune atrophic gastritis","volume":"10","author":"Neumann","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20180830111349_CIT0013","first-page":"83","article-title":"Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection","volume":"16","author":"Veijola","year":"2010","journal-title":"World J Gastroenterol"},{"key":"key\n\t\t\t\t20180830111349_CIT0014","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/00365529850166266","article-title":"The risk of gastric carcinoma and carcinoid tumours in patients with pernicious anaemia: a prospective follow-up study","volume":"33","author":"Kokkola","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t20180830111349_CIT0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/apt.12177","article-title":"Systematic review: gastric cancer incidence in pernicious anaemia","volume":"37","author":"Vannella","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20180830111349_CIT0016","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3748\/wjg.v18.i12.1279","article-title":"Risk for gastric neoplasias in patients with chronic atrophic gastritis: a critical reappraisal","volume":"18","author":"Vannella","year":"2012","journal-title":"World J Gastroenterol"},{"key":"key\n\t\t\t\t20180830111349_CIT0017","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis. The updated Sydney system. International workshop on the histopathology of gastritis, Houston 1994","volume":"20","author":"Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t20180830111349_CIT0018","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cca.2008.12.014","article-title":"Gastropanel: evaluation of the usefulness in the diagnosis of gastro-duodenal mucosal alterations in children","volume":"402","author":"Guariso","year":"2009","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t20180830111349_CIT0019","doi-asserted-by":"crossref","first-page":"520970","DOI":"10.1155\/2012\/520970","article-title":"Clinical usefulness of the serological gastric biopsy for the diagnosis of chronic autoimmune gastritis","volume":"2012","author":"Antico","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"key\n\t\t\t\t20180830111349_CIT0020","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1365-2036.2010.04277.x","article-title":"Gastritis OLGA-staging and gastric cancer risk: a twelve-year clinico-pathological follow-up study","volume":"31","author":"Rugge","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20180830111349_CIT0021","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.autrev.2014.01.048","article-title":"Diagnosis and classification of autoimmune gastritis","volume":"13","author":"Toh","year":"2014","journal-title":"Autoimmun Rev"},{"key":"key\n\t\t\t\t20180830111349_CIT0022","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1182\/blood-2005-09-3534","article-title":"Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion","volume":"107","author":"Hershko","year":"2006","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180830111349_CIT0023","first-page":"766","article-title":"High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anemia: a prospective screening study","volume":"94","author":"Marignani","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20180830111349_CIT0024","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1056\/NEJM199711133372007","article-title":"Pernicious anemia","volume":"337","author":"Toh","year":"1997","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180830111349_CIT0025","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.bpg.2014.10.005","article-title":"Chronic gastritis\u2014an update","volume":"28","author":"Varbanova","year":"2014","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"key\n\t\t\t\t20180830111349_CIT0026","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1038\/ajg.2009.231","article-title":"Reassessment of intrinsic factor and parietal cell autoantibodies in atrophic gastritis with respect to cobalamin deficiency","volume":"104","author":"Lahner","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20180830111349_CIT0027","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1083-4389.2001.00032.x","article-title":"Two-thirds of atrophic body gastritis patients have evidence of Helicobacter pylori infection","volume":"6","author":"Annibale","year":"2001","journal-title":"Helicobacter"},{"key":"key\n\t\t\t\t20180830111349_CIT0028","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.autrev.2010.08.006","article-title":"Autoantibodies to parietal cells as predictors of atrophic body gastritis: a five-year prospective study in patients with autoimmune thyroid diseases","volume":"10","author":"Tozzoli","year":"2010","journal-title":"Autoimmun Rev"},{"key":"key\n\t\t\t\t20180830111349_CIT0029","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1158\/1055-9965.EPI-12-1343","article-title":"Gastric parietal cell antibodies, Helicobacter pylori infection, and chronic atrophic gastritis: evidence from a large population-based study in Germany","volume":"22","author":"Zhang","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t20180830111349_CIT0030","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1073\/pnas.87.16.6418","article-title":"The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+\/K(+)-atpase (proton pump)","volume":"87","author":"Toh","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180830111349_CIT0031","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0167-5699(00)01653-4","article-title":"The causative H+\/K+ ATPase antigen in the pathogenesis of autoimmune gastritis","volume":"21","author":"Toh","year":"2000","journal-title":"Immunol Today"},{"key":"key\n\t\t\t\t20180830111349_CIT0032","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1172\/JCI113344","article-title":"Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach","volume":"81","author":"Karlsson","year":"1988","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180830111349_CIT0033","article-title":"Goldkorn I, Gleeson PA, Toh BH. Gastric parietal cell antigens of 60-90, 92, and 100-120 kDa associated with autoimmune gastritis and pernicious anemia: role of N-glycans in the structure and antigenicity of the 60-90-kDa component. J Biol Chem. 1989;264:18768-18774"},{"key":"key\n\t\t\t\t20180830111349_CIT0034","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.imlet.2012.06.004","article-title":"Factors associated with parietal cell autoantibodies in the general population","volume":"147","author":"Cabrera de Le\u00f3n","year":"2012","journal-title":"Immunol Lett"},{"key":"key\n\t\t\t\t20180830111349_CIT0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3109\/08916934.2012.702813","article-title":"Parietal cell antibody identified by ELISA is superior to immunofluorescence, rises with age and is associated with intrinsic factor antibody","volume":"45","author":"Toh","year":"2012","journal-title":"Autoimmunity"},{"key":"key\n\t\t\t\t20180830111349_CIT0036","first-page":"11","article-title":"Evaluation of an ELISA for detection of anti-parietal cell antibody","volume":"53","author":"Sugiu","year":"2006","journal-title":"Hepatogastroenterology"},{"key":"key\n\t\t\t\t20180830111349_CIT0037","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.33549\/physiolres.931498","article-title":"Anti-Helicobacter pylori, anti-thyroid peroxidase, anti-thyroglobulin and anti-gastric parietal cells antibodies in Czech population","volume":"57","author":"Sterzl","year":"2008","journal-title":"Physiol Res"},{"key":"key\n\t\t\t\t20180830111349_CIT0038","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cca.2009.12.012","article-title":"Prevalence of gastric parietal cell antibodies and intrinsic factor antibodies in primary biliary cirrhosis","volume":"411","author":"Liaskos","year":"2010","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t20180830111349_CIT0039","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/PAP.0b013e31828d185d","article-title":"Neuroendocrine proliferations of the stomach: a pragmatic approach for the perplexed pathologist","volume":"20","author":"Cockburn","year":"2013","journal-title":"Adv Anat Pathol"},{"key":"key\n\t\t\t\t20180830111349_CIT0040","first-page":"198","article-title":"Diagnostic efficacy of a specific serological profile for the diagnosis of chronic autoimmune gastritis","volume":"6","author":"Antico","year":"2010","journal-title":"Riv Ital Med Lab"},{"key":"key\n\t\t\t\t20180830111349_CIT0041","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7326\/0003-4819-134-5-200103060-00010","article-title":"Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated","volume":"134","author":"Ohkusa","year":"2001","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20180830111349_CIT0042","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1210\/jc.2005-0580","article-title":"Serum pepsinogen I: an early marker of pernicious anemia in patients with type 1 diabetes","volume":"90","author":"Alonso","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20180830111349_CIT0043","first-page":"125","article-title":"Autoimmune gastritis","volume":"4","author":"Antico","year":"2008","journal-title":"Riv Ital Med Lab"},{"key":"key\n\t\t\t\t20180830111349_CIT0044","doi-asserted-by":"crossref","first-page":"e1440","DOI":"10.1097\/MD.0000000000001440","article-title":"Type 1 diabetic populations have an increased prevalence of parietal cell antibody: a systematic review and meta-analysis","volume":"94","author":"Pan","year":"2015","journal-title":"Medicine (Baltimore)"}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/150\/4\/285\/25629878\/aqy061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T22:16:32Z","timestamp":1720304192000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/150\/4\/285\/5051640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,7,10]]},"published-print":{"date-parts":[[2018,8,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqy061","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10]]},"published":{"date-parts":[[2018,7,10]]}}}