{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:55:13Z","timestamp":1793055313984,"version":"4.5.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Reference values for placental weights correlated with gestational age are used in surgical pathology. Most reference values were established for fresh placentas. Some laboratories routinely fix all placentas, bringing into question the accuracy of the reference weight values. We wanted to determine the impact of fixation on placental weight.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred placentas from uncomplicated pregnancies were weighed in the fresh state, after removal of the cord and membranes. After fixation in formalin for 1 day and 5 days, the placentas were reweighed. The change in weight for each placenta was analyzed by a two-tailed paired t test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Statistically, a small but significant gain in weight occurred after 24 hours (3.7%, P &lt;&lt; .001), and there was no significant change identified in the additional 4 days (P = .51). Nine placentas lost weight with fixation; the weight of four was unchanged.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We consider formalin fixation to add a statistically significant but clinically negligible amount of weight to the placenta.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqz033","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T16:12:39Z","timestamp":1553184759000},"page":"217-220","source":"Crossref","is-referenced-by-count":12,"title":["The Difference Between Unfixed and Postfixation Placental Weight"],"prefix":"10.1093","volume":"152","author":[{"given":"Rosemary","family":"Tambouret","sequence":"first","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Jeck","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drucilla J","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Pathology, Massachusetts General Hospital, Boston"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"2019070505425605400_CIT0001","article-title":"In: King DW, ed. Placental pathology.","volume-title":"Atlas of Nontumor Pathology","author":"Kraus"},{"key":"2019070505425605400_CIT0002","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1080\/15513819609168713","article-title":"Reference values for singleton and twin placental weights","volume":"16","author":"Pinar","year":"1996","journal-title":"Pediatr Pathol Lab Med."},{"key":"2019070505425605400_CIT0003","first-page":"491","volume-title":"Pathology of the Placenta: Major Problems in Pathology","author":"Fox","year":"1978"},{"key":"2019070505425605400_CIT0004","first-page":"327","article-title":"Relationship of fetal and placental weight in human beings: fetal\/placental weight ratios at various gestational ages and birth weight distributions","volume":"21","author":"Molteni","year":"1978","journal-title":"J Reprod Med."},{"key":"2019070505425605400_CIT0005","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.placenta.2010.10.008","article-title":"Placenta weight percentile curves for singleton and twins deliveries","volume":"32","author":"Almog","year":"2011","journal-title":"Placenta."},{"key":"2019070505425605400_CIT0006","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ejogrb.2005.10.032","article-title":"Reference values for the weight of freshly delivered term placentas and for placental weight-birth weight ratios","volume":"128","author":"Burkhardt","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol."},{"key":"2019070505425605400_CIT0007","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.ajog.2004.02.023","article-title":"Updating reference values for placental weights in northern Alberta","volume":"190","author":"Dy","year":"2004","journal-title":"Am J Obstet Gynecol."},{"key":"2019070505425605400_CIT0008","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1471-0528.2007.01327.x","article-title":"Placenta weight percentile curves for singleton deliveries","volume":"114","author":"Thompson","year":"2007","journal-title":"BJOG."},{"key":"2019070505425605400_CIT0009","first-page":"1","article-title":"Normative values for placental weights (N = 15,463)","volume-title":"Mod Pathol.","author":"Boyd","year":"1999"},{"key":"2019070505425605400_CIT0010","first-page":"726","article-title":"The effect of immersion formaldehyde fixation on human placental weight","volume":"115","author":"Fox","year":"1991","journal-title":"Arch Pathol Lab Med."}],"container-title":["American Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajcp\/advance-article-pdf\/doi\/10.1093\/ajcp\/aqz033\/28683971\/aqz033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ajcp\/article-pdf\/152\/2\/217\/28905825\/aqz033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T05:43:09Z","timestamp":1562305389000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajcp\/article\/152\/2\/217\/5494664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,22]]},"published-print":{"date-parts":[[2019,7,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ajcp\/aqz033","relation":{},"ISSN":["0002-9173","1943-7722"],"issn-type":[{"value":"0002-9173","type":"print"},{"value":"1943-7722","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,8]]},"published":{"date-parts":[[2019,5,22]]}}}