{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:32:16Z","timestamp":1773869536026,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14\/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqz043","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T04:08:47Z","timestamp":1553486927000},"page":"132-145","source":"Crossref","is-referenced-by-count":7,"title":["Mantle Cell Lymphoma With Mantle Zone Growth Pattern"],"prefix":"10.1093","volume":"152","author":[{"given":"Ji","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, MD Anderson Cancer Center, Houston, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Duke University Medical Center, Durham, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijun Jeanna","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California, Davis, Sacramento"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University, Baltimore, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University, Baltimore, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette M","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Nebraska Medical Center, Omaha"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematopathology, MD Anderson Cancer Center, Houston, TX"},{"name":"Department of Pathology, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Advocate Christ Medical Center, Oak Lawn, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, New York University Langone Medical Center, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Indiana University, 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