{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:38:53Z","timestamp":1792143533975,"version":"4.4.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T00:00:00Z","timestamp":1559865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Rare cases of clonally related histiocytic sarcoma (HS) following B-lymphoblastic leukemia\/lymphoma (B-ALL\/LBL) have been reported to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present a patient with HS, which appeared as a breast mass 12 months after the initial diagnosis of B-ALL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both HS and the B-ALL shared IGH-MYC and IGK gene rearrangements. Next-generation sequencing and whole-exome sequencing (WES) studies detected 35 common mutations, as well as mutations unique to B-ALL (16) and HS (15), including BRAF D594G. The patient achieved complete remission of B-ALL, but HS failed to respond to many cycles of intensive chemotherapy regimens. A partial response was achieved with sorafenib, a BRAF-targeted therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first study to demonstrate by WES that clonally related B-ALL and HS arise through divergent evolution from a common precursor. We present our findings together with a discussion of the previously reported cases of HS in patients with B-ALL.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqz056","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T17:51:54Z","timestamp":1556560314000},"page":"486-494","source":"Crossref","is-referenced-by-count":8,"title":["Histiocytic Sarcoma Following B-Lymphoblastic Leukemia\/Lymphoma"],"prefix":"10.1093","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-6139","authenticated-orcid":false,"given":"Julia T","family":"Geyer","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine\/NewYork-Presbyterian Hospital, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Yigit","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine\/NewYork-Presbyterian Hospital, New York, 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