{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:48:46Z","timestamp":1791434926863,"version":"4.3.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Division of Anatomic Pathology, Mayo Clinic"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Long-term follow-up is important for determining performance characteristics of thyroid fine-needle aspiration (FNA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Histologic or 3 or more years of clinical follow-up was used to calculate performance characteristics of thyroid FNA before and after implementation of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). The impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) classification was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Follow-up was obtained for 1,277\/1,134 and 1,616\/1,393 aspirates\/patients (median clinical follow-up, 9.9 and 4.4 years, pre- and post-TBSRTC, respectively). Nondiagnostic, suspicious for follicular neoplasm, and suspicious for malignancy (SFM) diagnoses decreased and benign diagnoses increased post-TBSRTC, while atypical rate remained less than 1%. Negative predictive value for benign nodules and positive predictive value (PPV) for SFM increased significantly. Eleven nodules were reclassified as NIFTP, slightly decreasing PPV\/risk of malignancy (ROM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Appropriate ROM for thyroid FNA can be achieved through application of TBSRTC terminology with minimal use of atypical category.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqz076","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T19:20:23Z","timestamp":1557861623000},"page":"502-511","source":"Crossref","is-referenced-by-count":30,"title":["Assessment of The Bethesda System for Reporting Thyroid Cytopathology"],"prefix":"10.1093","volume":"152","author":[{"given":"Jennifer L","family":"Sauter","sequence":"first","affiliation":[{"name":"Division of Anatomic Pathology, Mayo Clinic, Rochester, MN"},{"name":"Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Lehrke","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamah T","family":"Al Badri","sequence":"additional","affiliation":[{"name":"Division of Anatomic Pathology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Rodriguez-Gutierrez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Mayo Clinic, Rochester, MN"},{"name":"KER-Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, MN"},{"name":"Plataforma INVEST Medicina UANL-KER Unit Mayo Clinic (KER Unit Mexico)"},{"name":"Endocrinology Division, Department of Internal Medicine, University Hospital \u201cDr. Jose E. 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