{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:36:30Z","timestamp":1782513390258,"version":"3.54.5"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA054419"],"award-info":[{"award-number":["R01CA054419"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Genital talc use is associated with increased risk for ovarian carcinoma in epidemiologic studies. Finding talc in pelvic tissues in women with ovarian carcinoma who have used talc is important in documenting exposure and assessing talc\u2019s biologic potential, but tissue-based morphology studies have been rarely reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report five patient cases with documented perineal talc use, each of whom had talc (by both polarized light and scanning electron microscopy) in multiple pelvic sites distant from the perineum. Six negative-exposure control patients were also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Talc particles were found in exposed patients, typically within two or more of the following locations: pelvic region lymph nodes, cervix, uterine corpus, fallopian tubes, and ovaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our report adds new insights into the biologic potential of talc and suggests additional anatomic sites that should be closely examined for talc by oncologic surgical pathologists in the setting of perineal talc use.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ajcp\/aqz080","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T19:26:17Z","timestamp":1558466777000},"page":"590-607","source":"Crossref","is-referenced-by-count":15,"title":["Migration of Talc From the Perineum to Multiple Pelvic Organ Sites"],"prefix":"10.1093","volume":"152","author":[{"given":"Sandra A","family":"McDonald","sequence":"first","affiliation":[{"name":"John J. Godleski, MD, PLLC, Milton, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Fan","sequence":"additional","affiliation":[{"name":"John J. Godleski, MD, PLLC, Milton, MA"},{"name":"Electron Microscopy Laboratory, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA"},{"name":"Boston University School of Dental Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Cramer","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Epidemiology Center, Brigham and Women\u2019s Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Godleski","sequence":"additional","affiliation":[{"name":"John J. 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Chan School of Public Health, Boston, MA"},{"name":"Department of Pathology, Brigham and Women\u2019s Hospital, Boston, MA"},{"name":"Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"2019100712584464300_CIT0001","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/1097-0142(19820715)50:2<372::AID-CNCR2820500235>3.0.CO;2-S","article-title":"Ovarian cancer and talc: a case-control study","volume":"50","author":"Cramer","year":"1982","journal-title":"Cancer."},{"key":"2019100712584464300_CIT0002","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<351::AID-IJC7>3.0.CO;2-M","article-title":"Genital talc exposure and risk of ovarian cancer","volume":"81","author":"Cramer","year":"1999","journal-title":"Int J Cancer."},{"key":"2019100712584464300_CIT0003","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/EDE.0000000000000434","article-title":"The association between talc use and ovarian cancer: a retrospective case-control study in two US states","volume":"27","author":"Cramer","year":"2016","journal-title":"Epidemiology."},{"key":"2019100712584464300_CIT0004","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-15-1281","article-title":"Association between body powder use and ovarian cancer: the African American Cancer Epidemiology Study (AACES)","volume":"25","author":"Schildkraut","year":"2016","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"2019100712584464300_CIT0005","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1158\/1940-6207.CAPR-13-0037","article-title":"Genital powder use and risk of ovarian cancer: a pooled analysis of 8525 cases and 9859 controls","volume":"6","author":"Terry","year":"2013","journal-title":"Cancer Prev Res (Phila)."},{"key":"2019100712584464300_CIT0006","first-page":"277","volume-title":"World Health Organization, International Agency for Research on Cancer. 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