{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:23:47Z","timestamp":1761920627607,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600168","81702082"],"award-info":[{"award-number":["81600168","81702082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic Research Project of Shenzhen Science and Technology Program","award":["JCYJ20160422145031770"],"award-info":[{"award-number":["JCYJ20160422145031770"]}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["SZSM201512006"],"award-info":[{"award-number":["SZSM201512006"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Mantle cell lymphoma (MCL) is a mature B-cell lymphoma characterized by CCND1\/IGH rearrangement. We reported a case of MCL harboring both CCND1\/IGH and MYC\/IGH rearrangements that also presented with an aggressive clinical course.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Biopsy specimens were evaluated by morphological staining, immunohistochemistry, flow cytometry, conventional cytogenetics, fluorescence in situ hybridization (FISH), and next-generation sequencing (NGS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Morphological and immunohistochemical staining of gallbladder samples demonstrated blastoid variant MCL. However, in the bone marrow sample, FISH indicated rearrangements in CCND1\/IGH and MYC\/IGH. Flow cytometry identified two groups of malignant lymphocytes. We sorted these two groups of cells. NGS then revealed that both cell types carried CCND1\/IGH rearrangements and TP53 mutations. Furthermore, the CD19+\/CD10+ cells carried additional MYC\/IGH rearrangement and NOTCH2 mutation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The rearrangement of MYC and a mutation in NOTCH2 probably induced the transformation of MCL cells in this patient. This uncommon double-hit MCL case clearly demonstrates a transformation process.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ajcp\/aqz133","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T15:09:16Z","timestamp":1562684956000},"page":"49-57","source":"Crossref","is-referenced-by-count":8,"title":["An Uncommon Case of Double-Hit Mantle Cell Lymphoma That Demonstrates a Transformation Process"],"prefix":"10.1093","volume":"153","author":[{"given":"Jihao","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Medicine Research Center, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9278-089X","authenticated-orcid":false,"given":"Xinyou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Second Clinical Medical College of Jinan University, Shenzhen People\u2019s Hospital, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"2019121321381023600_CIT0001","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/ajh.25487","article-title":"Mantle cell lymphoma: 2019 update on the diagnosis, pathogenesis, prognostication, and management","volume":"94","author":"Jain","year":"2019","journal-title":"Am J Hematol."},{"key":"2019121321381023600_CIT0002","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3892\/ijo.2015.3295","article-title":"Identification of miR-15b as a transformation-related factor in mantle cell lymphoma","volume":"48","author":"Arakawa","year":"2016","journal-title":"Int J Oncol."},{"key":"2019121321381023600_CIT0003","doi-asserted-by":"crossref","first-page":"E116","DOI":"10.3390\/genes8040116","article-title":"The role of c-MYC in B-cell lymphomas: diagnostic and molecular aspects","volume":"8","author":"Nguyen","year":"2017","journal-title":"Genes."},{"key":"2019121321381023600_CIT0004","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1182\/blood-2010-09-297879","article-title":"Double-hit B-cell lymphomas","volume":"117","author":"Aukema","year":"2011","journal-title":"Blood."},{"key":"2019121321381023600_CIT0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000353118","article-title":"Cytogenetic nomenclature: changes in the ISCN 2013 compared to the 2009 edition","volume":"141","author":"Simons","year":"2013","journal-title":"Cytogenet Genome Res."},{"key":"2019121321381023600_CIT0006","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s12032-014-0931-6","article-title":"Mantle cell lymphoma harboring Burkitt\u2019s-like translocations presents differential expression of aurora kinase genes compared with others 8q abnormalities","volume":"31","author":"de Oliveira","year":"2014","journal-title":"Med Oncol."},{"key":"2019121321381023600_CIT0007","first-page":"155","article-title":"Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature","volume":"6","author":"Setoodeh","year":"2013","journal-title":"Int J Clin Exp Pathol."},{"key":"2019121321381023600_CIT0008","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3109\/10428194.2012.710329","article-title":"An aggressive B-cell lymphoma with rearrangements of MYC and CCND1 genes: a rare subtype of double-hit lymphoma","volume":"54","author":"Durot","year":"2013","journal-title":"Leuk Lymphoma."},{"key":"2019121321381023600_CIT0009","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3343\/alm.2012.32.1.95","article-title":"CD5-negative blastoid variant mantle cell lymphoma with complex CCND1\/IGH and MYC aberrations","volume":"32","author":"Seok","year":"2012","journal-title":"Ann Lab Med."},{"key":"2019121321381023600_CIT0010","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/ajcp\/aqw194","article-title":"CCND1-IGH fusion-amplification and MYC copy number gain in a case of pleomorphic variant mantle cell lymphoma","volume":"146","author":"Miao","year":"2016","journal-title":"Am J Clin Pathol."},{"key":"2019121321381023600_CIT0011","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/his.12760","article-title":"MYC overexpression correlates with MYC amplification or translocation, and is associated with poor prognosis in mantle cell 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