{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:22:37Z","timestamp":1793910157710,"version":"4.8.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this report is to describe the lung biopsy findings in vaping-associated pulmonary illness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lung biopsies from eight patients with vaping-associated pulmonary illness were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The biopsies were from eight men (aged 19-61 years) with respiratory symptoms following e-cigarette use (vaping). Workup for infection was negative in all cases, and there was no evidence for other etiologies. Imaging showed diffuse bilateral ground-glass opacities in all patients. Most recovered with corticosteroid therapy, while one died. Lung biopsies (seven transbronchial, one surgical) showed acute lung injury, including organizing pneumonia and\/or diffuse alveolar damage. Common features were fibroblast plugs, hyaline membranes, fibrinous exudates, type 2 pneumocyte hyperplasia, and interstitial organization. Some cases featured a sparse interstitial chronic inflammatory infiltrate. Although macrophages were present within the airspaces in all cases, this feature was not prominent, and findings typical of exogenous lipoid pneumonia were absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The histopathology of acute pulmonary illness related to e-cigarette use (vaping) is characterized by acute lung injury patterns, supporting the contention that vaping can cause severe lung damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqz182","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T15:29:45Z","timestamp":1570202985000},"source":"Crossref","is-referenced-by-count":44,"title":["Lung Biopsy Findings in Severe Pulmonary Illness Associated With E-Cigarette Use (Vaping)"],"prefix":"10.1093","author":[{"given":"Sanjay","family":"Mukhopadhyay","sequence":"first","affiliation":[{"name":"Department of Pathology, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Mehrad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Dammert","sequence":"additional","affiliation":[{"name":"Kent Pulmonary Associates, Dover, DE"},{"name":"Bayhealth Medical Center, Dover, DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea V","family":"Arrossi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Sarda","sequence":"additional","affiliation":[{"name":"UnityPoint Health\u2014Meriter Hospital, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Brenner","sequence":"additional","affiliation":[{"name":"Bayhealth Medical Center, Dover, DE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Choi","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ghobrial","sequence":"additional","affiliation":[{"name":"Respiratory Institute, Cleveland Clinic, Cleveland, 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