{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:33:29Z","timestamp":1787589209172,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous category with a broad range of underlying genetic abnormalities. We investigated the significance of genetic factors in a large series of AML-MRC cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The morphologic findings, genetic data, and patient outcomes were assessed in 186 AML-MRC cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median overall survival (OS) was dismal in AML-MRC patients (median, 7.6 months; 95% confidence interval, 5-10.6 months). Karyotypically normal cases and cytogenetically abnormal cases without myelodysplastic syndrome (MDS)-related cytogenetic abnormalities showed similar OS, significantly better than cases carrying MDS-related cytogenetic abnormalities. MDS-related cytogenetic abnormalities, monosomal or complex karyotype, and history of MDS or myelodysplastic\/myeloproliferative neoplasm were all associated with dismal outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AML-MRC predicts a poor prognosis. Our study supports the finding that the genetic profile plays a key role in determining prognosis in AML-MRC as defined according to the World Health Organization revised fourth edition (2017) diagnostic criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ajcp\/aqz206","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T07:08:09Z","timestamp":1575356889000},"page":"656-663","source":"Crossref","is-referenced-by-count":20,"title":["Genetic Factors in Acute Myeloid Leukemia With Myelodysplasia-Related Changes"],"prefix":"10.1093","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-5959","authenticated-orcid":false,"given":"Hong","family":"Fang","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"He","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Chiu","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Viswanatha","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhett P","family":"Ketterling","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Rochester, MN"},{"name":"Division of Laboratory Genetics, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mrinal S","family":"Patnaik","sequence":"first","affiliation":[{"name":"Division of Hematology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaaren K","family":"Reichard","sequence":"first","affiliation":[{"name":"Division of Hematopathology, Rochester, 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