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The model is used to quantify the effectiveness of therapy for early latent tuberculosis infection in reducing the prevalence of active tuberculosis. The model is also used to demonstrate how effective therapy for early latent tuberculosis infection has to be to eliminate tuberculosis, when used in conjunction with therapy for active tuberculosis. Analysis of the model suggests that programs such as contact investigations, which identify and treat persons recently infected with Mycobacterium tuberculosis, may have a substantial effect on controlling tuberculosis epidemics.<\/jats:p>","DOI":"10.1093\/aje\/153.4.381","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:55:22Z","timestamp":1027724122000},"page":"381-385","source":"Crossref","is-referenced-by-count":100,"title":["Early Therapy for Latent Tuberculosis Infection"],"prefix":"10.1093","volume":"153","author":[{"given":"Elad","family":"Ziv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L.","family":"Daley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally M.","family":"Blower","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,2,15]]},"reference":[{"key":"2024100810182487200_B1","unstructured":"Ferebee S. 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