{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:27:28Z","timestamp":1728448048460},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although perforation of the appendix is considered a risk factor for female tubal infertility, the epidemiologic evidence supporting this relation is inconsistent. Risk factors for tubal infertility were compared for 121 women with documented primary tubal infertility attending in vitro fertilization clinics in Toronto, Canada, from July to December 1998 and 490 controls who were pregnant during the same time period. Self-administered questionnaires and review of medical records were used to assess exposures. The authors found that neither history of acute appendicitis nor perforation of the appendix was a statistically significant risk factor for tubal infertility. The crude odds ratio for perforated appendicitis was 3.4 (95% confidence interval (CI): 0.9, 12.9), and the adjusted odds ratio was 1.4 (95% CI: 0.3, 6.2). In addition to increased age and annual income, cigarette smoking (odds ratio (OR) = 2.0, 95% CI: 1.2, 3.2), history of endometriosis (OR = 6.0, 95% CI: 2.8,12.8), and history of pelvic inflammatory disease (OR = 6.0, 95% CI: 2.8, 12.8) were significantly associated with tubal infertility in multivariate analysis. These data do not provide substantial evidence that perforation of the appendix is an important risk factor for female tubal infertility.<\/jats:p>","DOI":"10.1093\/aje\/153.6.566","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T23:02:40Z","timestamp":1027724560000},"page":"566-571","source":"Crossref","is-referenced-by-count":22,"title":["Association of Perforation of the Appendix with Female Tubal Infertility"],"prefix":"10.1093","volume":"153","author":[{"given":"David R.","family":"Urbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loraine D.","family":"Marrett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Kung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,3,15]]},"reference":[{"key":"2024100810183884600_B1","unstructured":"Wiig JN, Janssen CW, Fuglesang P, et al. Infertility as a complication of perforated appendicitis: late follow-up of a clinical series. Acta Chir Scand\n\u00a01979;145:409\u201310."},{"key":"2024100810183884600_B2","unstructured":"Forsell P, Pieper R. Infertility in young women due to perforated appendicitis? Acta Chir Scand\n\u00a01986;530:59\u201360."},{"key":"2024100810183884600_B3","doi-asserted-by":"crossref","unstructured":"Geerdsen J, Hansen JB. Incidence of sterility in women operated on in childhood for perforated appendicitis. Acta Obstet Gynecol Scand\n\u00a01977;56:523\u20134.","DOI":"10.3109\/00016347709155024"},{"key":"2024100810183884600_B4","doi-asserted-by":"crossref","unstructured":"Thompson WM, Lynn HB. The possible relationship of appendicitis with perforation in childhood to infertility in women. J Pediatr Surg\n\u00a01971;6:458\u201361.","DOI":"10.1016\/S0022-3468(71)80008-8"},{"key":"2024100810183884600_B5","doi-asserted-by":"crossref","unstructured":"Lalos O. 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