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Using data from the LEGACY Girls Study (North America, 2011\u20132016), we prospectively examined the associations between childhood viral infections (cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV) 1, HSV2) and pubertal timing. We measured exposures based on seropositivity in premenarcheal girls (n\u00a0= 490). Breast and pubic hair development were classified based on mother-reported Tanner Stage (TS) (TS2+ compared with TS1), adjusting for age, body mass index, and sociodemographic factors. The average age at first blood draw was 9.8 years (standard deviation, 1.9 years). The prevalences were 31% CMV+, 37% EBV+, 14% HSV1+, 0.4% HSV2+, and 16% for both CMV+\/EBV+ coinfection. CMV+ infection without coinfection was associated with developing breasts an average of 7 months earlier (hazard ratio (HR)\u00a0= 2.12, 95% confidence interval (CI): 1.32, 3.40). CMV infection without coinfection and HSV1 and\/or HSV2 infection were associated with developing pubic hair 9 months later (HR\u00a0= 0.41, 95% CI: 0.24, 0.71, and HR\u00a0= 0.42, 95% CI: 0.22, 0.81, respectively). Infection was not associated with menarche. If replicated in larger cohorts with blood collection prior to any breast development, this study supports the hypothesis that childhood infections might play a role in altering pubertal timing.<\/jats:p>","DOI":"10.1093\/aje\/kwaa240","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T12:09:46Z","timestamp":1603973386000},"page":"766-778","source":"Crossref","is-referenced-by-count":7,"title":["Common Childhood Viruses and Pubertal Timing: The LEGACY Girls Study"],"prefix":"10.1093","volume":"190","author":[{"given":"Jasmine A","family":"McDonald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinaida","family":"Cherubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Mary","family":"Schooling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina M","family":"Santella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela R","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saundra S","family":"Buys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene L","family":"Andrulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M","family":"John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Terry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"issue":"3","key":"2021050421272742100_ref1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000336325","article-title":"Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty","volume":"77","author":"S\u00f8rensen","year":"2012","journal-title":"Horm Res Paediatr"},{"issue":"5","key":"2021050421272742100_ref2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1210\/er.2002-0019","article-title":"The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration","volume":"24","author":"Parent","year":"2003","journal-title":"Endocr Rev"},{"issue":"5","key":"2021050421272742100_ref3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jadohealth.2010.05.018","article-title":"The timing of puberty: is it changing? 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