{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:02:36Z","timestamp":1787068956967,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107"],"award-info":[{"award-number":["UM1 CA186107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 CA87969"],"award-info":[{"award-number":["P01 CA87969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA176726"],"award-info":[{"award-number":["U01 CA176726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 CA167552"],"award-info":[{"award-number":["U01 CA167552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"VISN-1 Career Development Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ultraviolet radiation (UVR) exposure is the major risk factor for melanoma. However, epidemiologic studies on UVR and noncutaneous cancers have reported inconsistent results, with some suggesting an inverse relationship potentially mediated by vitamin D. To address this, we examined 3 US prospective cohorts, the Health Professionals Follow-up Study (HPFS) (1986) and Nurses\u2019 Health Study (NHS) I and II (1976 and 1989), for associations between cumulative erythemal UVR and incident cancer risk, excluding nonmelanoma skin cancer. We used a validated spatiotemporal model to calculate erythemal UVR. Participants (47,714 men; 212,449 women) were stratified into quintiles by cumulative average erythemal UVR, using the first quintile as referent, for Cox proportional hazards regression analysis. In the multivariable-adjusted meta-analysis of all cohorts, compared with the lowest quintile, risk of any cancer was slightly increased across all other quintiles (highest quintile hazard ratio (HR)\u00a0=\u00a01.04, 95% confidence interval (CI): 1.01, 1.07; P for heterogeneity\u00a0= 0.41). All UVR quintiles were associated with similarly increased risk of any cancer excluding melanoma. As expected, erythemal UVR was positively associated with risk of melanoma (highest quintile HR\u00a0=\u00a01.17, 95% CI: 1.04, 1.31; P for heterogeneity\u00a0= 0.83). These findings suggest that elevated UVR is associated with increased risk of both melanoma and noncutaneous cancers.<\/jats:p>","DOI":"10.1093\/aje\/kwac101","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T19:20:21Z","timestamp":1654629621000},"page":"1742-1752","source":"Crossref","is-referenced-by-count":7,"title":["Cumulative Erythemal Ultraviolet Radiation and Risk of Cancer in 3 Large US Prospective Cohorts"],"prefix":"10.1093","volume":"191","author":[{"given":"Michael S","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca I","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Trepanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward L","family":"Giovannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"issue":"14","key":"2023030803050529500_","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1200\/JCO.2011.39.3652","article-title":"Use of tanning beds and incidence of skin cancer","volume":"30","author":"Zhang","year":"2012","journal-title":"J Clin Oncol."},{"issue":"3","key":"2023030803050529500_","first-page":"612","article-title":"Is occupational solar ultraviolet irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiological literature","volume":"165","author":"Bauer","year":"2011","journal-title":"Br J Dermatol."},{"issue":"5","key":"2023030803050529500_","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.3390\/molecules19056202","article-title":"Ultraviolet radiation, aging and the skin: prevention of damage by topical cAMP manipulation","volume":"19","author":"Amaro-Ortiz","year":"2014","journal-title":"Molecules."},{"key":"2023030803050529500_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-6-264","article-title":"Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993\u20132002","volume":"6","author":"Boscoe","year":"2006","journal-title":"BMC Cancer."},{"issue":"1","key":"2023030803050529500_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-017-0299-0","article-title":"Ambient ultraviolet radiation exposure and hepatocellular carcinoma incidence in the 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