{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:28:24Z","timestamp":1773764904160,"version":"3.50.1"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vertebral fractures have been associated with increased mortality, but findings are inconclusive, and many vertebral fractures avoid clinical attention. We investigated this association in a general population of 2,476 older adults aged \u226555 years from Troms\u00f8, Norway, who were followed over 2007\u20132020, using dual-energy x-ray absorptiometry (DXA) at baseline to evaluate vertebral fractures (mild, moderate, or severe). We used multiple Cox regression models to estimate hazard ratios (HRs) for all-cause mortality, adjusted for age, sex, body mass index, education, smoking, alcohol intake, cardiovascular disease, and respiratory disease. Mean follow-up in the cohort was 11.2 (standard deviation, 2.7) years; 341 participants (13.8%) had \u22651 vertebral fracture at baseline, and 636 participants (25.7%) died between baseline and follow-up. Full-adjustment models showed a nonsignificant association between vertebral fracture status (yes\/no) and mortality. Participants with \u22653 vertebral fractures (HR\u00a0= 2.43, 95% confidence interval: 1.57, 3.78) or \u22651 severe vertebral fracture (HR\u00a0= 1.65, 95% confidence interval: 1.26, 2.15) had increased mortality compared with those with no vertebral fractures. Dual-energy x-ray absorptiometry\u2013based screening could be a potent and feasible tool in detecting vertebral fractures that are often clinically silent yet independently associated with premature death. Our data indicated that detailed vertebral assessment could be warranted for a more accurate survival estimation.<\/jats:p>","DOI":"10.1093\/aje\/kwac161","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T12:45:20Z","timestamp":1663073120000},"page":"62-69","source":"Crossref","is-referenced-by-count":8,"title":["Vertebral Fractures Assessed by Dual-Energy X-Ray Absorptiometry and All-Cause Mortality: The Troms\u00f8 Study, 2007\u20132020"],"prefix":"10.1093","volume":"192","author":[{"given":"Jonas","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Emaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan","family":"Geelhoed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edvard","family":"Sagelv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Morseth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"issue":"5","key":"2023010805020920900_ref1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00198-017-3909-3","article-title":"Worldwide prevalence and incidence of osteoporotic vertebral fractures","volume":"28","author":"Ballane","year":"2017","journal-title":"Osteoporos Int."},{"key":"2023010805020920900_ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2474-13-3","article-title":"Prevalence of vertebral fractures in women and men in the population-based Troms\u00f8 Study","volume":"13","author":"Waterloo","year":"2012","journal-title":"BMC Musculoskelet Disord."},{"issue":"1","key":"2023010805020920900_ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00198-018-4704-5","article-title":"European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"30","author":"Kanis","year":"2019","journal-title":"Osteoporos Int."},{"issue":"3","key":"2023010805020920900_ref4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1359\/jbmr.061202","article-title":"Osteoporosis-related kyphosis and impairments in pulmonary function: a systematic review","volume":"22","author":"Harrison","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2023010805020920900_ref5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.bsd.0000211273.74238.0e","article-title":"Changes of pulmonary function for patients with osteoporotic vertebral compression fractures after kyphoplasty","volume":"20","author":"Yang","year":"2007","journal-title":"J Spinal Disord Tech."},{"issue":"1","key":"2023010805020920900_ref6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-2318-13-102","article-title":"Vertebral fractures and self-perceived health in elderly women and men in a population-based cross-sectional study: the Troms\u00f8 Study 2007\u201308","volume":"13","author":"Waterloo","year":"2013","journal-title":"BMC Geriatr."},{"issue":"3","key":"2023010805020920900_ref7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1001\/jama.285.3.320","article-title":"Risk of new vertebral fracture in the year following a fracture","volume":"285","author":"Lindsay","year":"2001","journal-title":"JAMA."},{"issue":"5","key":"2023010805020920900_ref8","doi-asserted-by":"crossref","first-page":"E280","DOI":"10.1097\/BRS.0000000000003264","article-title":"Mortality and cause of death in patients with vertebral fractures: a longitudinal follow-up study using a national sample cohort","volume":"45","author":"Choi","year":"2020","journal-title":"Spine (Phila Pa 1976)."},{"issue":"3","key":"2023010805020920900_ref9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1532-5415.2000.tb02641.x","article-title":"Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. 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