{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T05:25:06Z","timestamp":1784438706252,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rapid point-of-care tests that diagnose gonococcal infections and identify susceptibility to antibiotics enable individualized treatment. This could improve patient outcomes and slow the emergence and spread of antibiotic resistance. However, little is known about the long-term impact of such diagnostics on the burden of gonorrhea and the effective life span of antibiotics. We used a mathematical model of gonorrhea transmission among men who have sex with men in the United States to project the annual rate of reported gonorrhea cases and the effective life span of ceftriaxone, the recommended antibiotic for first-line treatment of gonorrhea, as well as 2 previously recommended antibiotics, ciprofloxacin and tetracycline, when a rapid drug susceptibility test that estimates susceptibility to ciprofloxacin and tetracycline is available. The use of a rapid drug susceptibility test with \u226550% sensitivity and\u00a0\u226595% specificity, defined in terms of correct ascertainment of drug susceptibility and nonsusceptibility status, could increase the combined effective life span of ciprofloxacin, tetracycline, and ceftriaxone by at least 2 years over 25 years of simulation. If test specificity is imperfect, however, the increase in the effective life span of antibiotics is accompanied by an increase in the rate of reported gonorrhea cases even under perfect sensitivity.<\/jats:p>","DOI":"10.1093\/aje\/kwad175","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:03:37Z","timestamp":1693004617000},"page":"17-25","source":"Crossref","is-referenced-by-count":10,"title":["The Impact of Rapid Drug Susceptibility Tests on Gonorrhea Burden and the Life Span of Antibiotic Treatments: A Modeling Study Among Men Who Have Sex With Men in the United States"],"prefix":"10.1093","volume":"193","author":[{"given":"Reza","family":"Yaesoubi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Gift","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancta B","family":"St. Cyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minttu M","family":"R\u00f6nn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan H","family":"Grad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"2024010814545276600_ref1","doi-asserted-by":"crossref","DOI":"10.15620\/cdc:82532","volume-title":"Antibiotic Resistance Threats in the United States, 2019","author":"Centres for Disease Control and Prevention","year":"2019"},{"key":"2024010814545276600_ref2","volume-title":"Sexually Transmitted Disease Surveillance 2020","author":"Centers for Disease Control and Prevention","year":"2020"},{"key":"2024010814545276600_ref3","volume-title":"Report on Global Sexually Transmitted Infection Surveillance 2018","author":"World Health Organization","year":"2018"},{"issue":"8","key":"2024010814545276600_ref4","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2471\/BLT.18.228486","article-title":"Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016","volume":"97","author":"Rowley","year":"2019","journal-title":"Bull World Health Organ."},{"issue":"19","key":"2024010814545276600_ref5","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1706988","article-title":"Single-dose zoliflodacin (ETX0914) for treatment of urogenital gonorrhea","volume":"379","author":"Taylor","year":"2018","journal-title":"N Engl J Med."},{"issue":"6","key":"2024010814545276600_ref6","article-title":"Efficacy, safety, and tolerability of gepotidacin (GSK2140944) in the treatment of patients with suspected or confirmed Gram-positive acute bacterial skin and skin structure infections","volume":"61","author":"O\u2019Riordan","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"issue":"7","key":"2024010814545276600_ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6507a1","article-title":"Neisseria gonorrhoeae antimicrobial susceptibility surveillance\u2014the Gonococcal Isolate Surveillance Project, 27 sites, United States, 2014","volume":"65","author":"Kirkcaldy","year":"2016","journal-title":"MMWR Surveill Summ."},{"issue":"2","key":"2024010814545276600_ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001598","article-title":"Molecular diagnostics for gonorrhoea: implications for antimicrobial resistance and the threat of untreatable gonorrhoea","volume":"11","author":"Low","year":"2014","journal-title":"PLoS Med."},{"issue":"19","key":"2024010814545276600_ref9","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1056\/NEJMp1812269","article-title":"Neisseria gonorrhoeae\u2014rising infection rates, dwindling treatment options","volume":"379","author":"Blank","year":"2018","journal-title":"N Engl J Med."},{"issue":"6","key":"2024010814545276600_ref10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJMp1112456","article-title":"The emerging threat of untreatable gonococcal infection","volume":"366","author":"Bolan","year":"2012","journal-title":"N Engl J Med."},{"key":"2024010814545276600_ref11","volume-title":"Gonococcal Isolate Surveillance Project (GISP) and Enhanced GISP (eGISP). 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