{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:20:18Z","timestamp":1789237218130,"version":"build-2803163510"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R03 CA241788-01A1"],"award-info":[{"award-number":["R03 CA241788-01A1"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our purpose was to investigate the associations between falls and oxaliplatin-induced peripheral neuropathy (OIPN), sociodemographic characteristics, and clinical characteristics of older patients with colorectal cancer. The study population consisted of older adults diagnosed with colorectal cancer whose data were obtained from the Surveillance, Epidemiology, and End Results database combined with Medicare claims. We defined OIPN using specific (OIPN 1) and broader (OIPN 2) definitions of OIPN, based on diagnosis codes. Extensions of the Cox regression model to accommodate repeated events were used to obtain overall hazard ratios (HRs) with 95% CIs and the cumulative hazard of fall. The unadjusted risk of fall for colorectal cancer survivors with versus without OIPN 1 at 36\u00a0months of follow-up was 19.6% versus 14.3%, respectively. The association of OIPN with time to fall was moderate (for OIPN 1, HR\u00a0=\u00a01.37; 95% CI, 1.04-1.79) to small (for OIPN 2, HR\u00a0=\u00a01.24; 95% CI, 1.01-1.53). Memantine, opioids, cannabinoids, prior history of fall, female sex, advanced age and disease stage, chronic liver disease, diabetes, and chronic obstructive pulmonary disease all increased the hazard rate of falling. Incorporating fall prevention in cancer care is essential to minimize morbidity and mortality of this serious event in older survivors of colorectal cancer.<\/jats:p>","DOI":"10.1093\/aje\/kwae067","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T06:58:21Z","timestamp":1715842701000},"page":"1271-1280","source":"Crossref","is-referenced-by-count":10,"title":["The associations of oxaliplatin-induced peripheral neuropathy, sociodemographic characteristics, and clinical characteristics with time to fall in older adults with colorectal cancer"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-3102","authenticated-orcid":false,"given":"Robert B","family":"Hines","sequence":"first","affiliation":[{"name":"University of Central Florida Department of Population Health Sciences, College of Medicine, , Orlando, FL 32827,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Schoborg","sequence":"additional","affiliation":[{"name":"University of Central Florida Department of Statistics and Data Science, College of Sciences, , Orlando, FL 32827,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Sumner","sequence":"additional","affiliation":[{"name":"University of Central Florida Department of Statistics and Data Science, College of Sciences, , Orlando, FL 32827,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana-Leigh","family":"Thiesfeldt","sequence":"additional","affiliation":[{"name":"University of Central Florida Department of Medical Education, College of Medicine, , Orlando, FL 32827,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunpu","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Central Florida Department of Statistics and Data Science, College of Sciences, , Orlando, FL 32827,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"2024101711203838000_ref1","volume-title":"SEER Cancer Statistics Review, 1975-2016. 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