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This is due to limitations of prior research, such as small sample sizes, reliance on manual record review, and limited analytic methods, that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite, retrospective registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases, 10th Revision (ICD-10) code\u2013defined hypertension disorder on or after January 1, 2015, and age\u00a0&amp;lt;\u00a019\u00a0years. We exclude patients with ICD-10 code\u2013defined pregnancy, kidney failure on dialysis, or kidney transplantation. Data include demographics, anthropomorphics, US Census Bureau tract, histories, blood pressure, ICD-10 codes, medications, laboratory and imaging results, and ambulatory blood pressure. SUPERHERO leverages expertise in epidemiology, statistics, clinical care, and biomedical informatics to create the largest and most diverse registry of youth with newly diagnosed hypertension disorders. SUPERHERO\u2019s goals are to reduce CVD burden across the life course and establish gold-standard biomedical informatics methods for youth with hypertension disorders.<\/jats:p>","DOI":"10.1093\/aje\/kwae116","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:20:06Z","timestamp":1718601606000},"page":"1650-1661","source":"Crossref","is-referenced-by-count":4,"title":["The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): rationale and methods"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3204-4142","authenticated-orcid":false,"given":"Andrew M","family":"South","sequence":"first","affiliation":[{"name":"Section of Nephrology , Department of Pediatrics, , Winston Salem, NC 27157 ,","place":["United States"]},{"name":"Wake Forest University School of Medicine , Department of Pediatrics, , Winston Salem, NC 27157 ,","place":["United States"]},{"name":"Department of Epidemiology and 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