{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:13:56Z","timestamp":1790763236912,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Laboratory Directed Research and Development (LDRD) Exploratory Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coccidioidomycosis, or Valley fever, is an infectious disease caused by inhaling Coccidioides fungal spores. Incidence has risen in recent years, and it is believed the endemic region for Coccidioides is expanding in response to climate change. While Valley fever case data can help us understand trends in disease risk, using case data as a proxy for Coccidioides endemicity is not ideal because case data suffer from imperfect detection, including false positives (eg, travel-related cases reported outside of endemic area) and false negatives (eg, misdiagnosis or underreporting). We proposed a Bayesian, spatio-temporal occupancy model to relate monthly, county-level presence\/absence data on Valley fever cases to latent endemicity of Coccidioides, accounting for imperfect detection. We used our model to estimate endemicity in the western United States. We estimated high probability of endemicity in southern California, Arizona, and New Mexico, but also in regions without mandated reporting, including western Texas, eastern Colorado, and southeastern Washington. We also quantified spatio-temporal variability in detectability of Valley fever, given an area is endemic to Coccidioides. We estimated an inverse relationship between lagged 3- and 9-month precipitation and case detection, and a positive association with agriculture. This work can help inform public health surveillance needs and identify areas that would benefit from mandatory case reporting.<\/jats:p>\n               <jats:p>This article is part of a Special Collection on Environmental Epidemiology.<\/jats:p>","DOI":"10.1093\/aje\/kwae199","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T02:17:51Z","timestamp":1721182671000},"page":"56-63","source":"Crossref","is-referenced-by-count":6,"title":["Estimating coccidioidomycosis endemicity while accounting for imperfect detection using spatio-temporal occupancy modeling"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-088X","authenticated-orcid":false,"given":"Staci A","family":"Hepler","sequence":"first","affiliation":[{"name":"Wake Forest University Department of Statistical Sciences, , Winston-Salem, NC 27109,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A","family":"Kaufeld","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory Statistical Sciences Group, , Los Alamos, NM 87545,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-3303","authenticated-orcid":false,"given":"David","family":"Kline","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine Department of Biostatistics and Data Science, , Winston-Salem, NC 27101,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Greene","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory Statistical Sciences Group, , Los Alamos, NM 87545,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan E","family":"Gorris","sequence":"additional","affiliation":[{"name":"Los Alamos National Laboratory Information Systems and Modeling Group, 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