{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:40:24Z","timestamp":1790818824072,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/\u00a0","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/\u00a0","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We conducted this systematic review and meta-analysis to clarify the trend of precocious puberty (PP) incidence after the COVID-19 outbreak and explore potential contributing factors, such as age at presentation and body mass index (BMI) SD score (SDS). Children visiting pediatric endocrinology clinics for the first time for suspected PP were included. We searched databases until February 28, 2023, for studies reporting various indicators of PP incidence before and during the pandemic. Total numbers of events and observations were recorded. A meta-analysis was performed to compare the odds of PP, BMI SDS, and age at presentation between the 2 periods. The dose-response relationships between time points (by number of years away from the pandemic) and PP risk were explored. In summary, a total of 32 studies including 24\u2009200 participants were recruited. The COVID-19 pandemic was associated with the increasing odds of PP among children referred for a suspicious condition (odds ratio = 1.96; 95% CI, 1.56-2.47; I2 = 54%; P\u00a0&amp;lt;\u00a0.001). Sensitivity analysis confirmed the robustness of the findings. The BMI SDS did not vary between the 2 periods, whereas age at presentation was lower after the pandemic. Precocious puberty incidence increased more rapidly during the pandemic period than during the prepandemic period. Trial registration: International Prospective Register of Systematic Reviews (PROSPERO; identifier: CRD42023402212)<\/jats:p>","DOI":"10.1093\/aje\/kwae295","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T18:09:04Z","timestamp":1724350144000},"page":"1131-1139","source":"Crossref","is-referenced-by-count":10,"title":["Difference in precocious puberty between pre\u2013COVID-19 and COVID-19 periods: a meta-analysis"],"prefix":"10.1093","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-2352","authenticated-orcid":false,"given":"Nam Nhat","family":"Nguyen","sequence":"first","affiliation":[{"name":"Endocrinology Clinic , Hanh Phuc International Hospital, Binh Duong 75207, Vietnam"},{"name":"College of Medicine , Taipei Medical University, Taipei,","place":["Taiwan 110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri Dang","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 749000,","place":["Vietnam"]},{"name":"Department of Nephrology and Endocrinology , Children\u2019s Hospital 1, Ho Chi Minh City 740500,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-8369","authenticated-orcid":false,"given":"Hieu Hong","family":"Truong","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension , Department of Internal Medicine, Mayo Clinic, Rochester, MN 55901,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh Nam","family":"Mai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine , College of Medicine and Pharmacy, Duy Tan University, Da Nang 50000,","place":["Vietnam"]},{"name":"Institute for Research and Training in Medicine , Biology and Pharmacy, Duy Tan University, Da Nang 50000,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-3716","authenticated-orcid":false,"given":"Yang-Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine , Wan Fang Hospital, Taipei Medical University, Taipei,","place":["Taiwan 116"]},{"name":"Department of Family Medicine , Taipei Medical University Hospital, Taipei Medical University, Taipei,","place":["Taiwan 110"]},{"name":"Department of Family Medicine , School of Medicine, College of Medicine, Taipei Medical University, Taipei,","place":["Taiwan 110"]},{"name":"School of Nutrition and Health Sciences , College of Nutrition, Taipei Medical University, Taipei,","place":["Taiwan 110"]},{"name":"Graduate Institute of Metabolism and Obesity Sciences , Taipei Medical University, Taipei,","place":["Taiwan 110"]},{"name":"Nutrition Research Center , Taipei Medical University Hospital, Taipei,","place":["Taiwan 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