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Few studies have explored these exposures in relation to multiple myeloma (MM) risk. To further evaluate these associations with NHL and MM risk and identify etiologically relevant exposure timing, we pooled data on 566\u2009693 individuals from 6\u00a0US prospective cohort studies (11\u2009636 incident NHL; 2749 incident MM; median follow-up: 20\u00a0years) and used geographic information systems models to estimate residential ambient UVR levels at time points from birth to adulthood. Using Cox proportional hazards models, we calculated hazard ratios (HRs) and 95% CIs for associations of residential ambient UVR levels with NHL overall, NHL subtypes, and MM, adjusted for study, age, and other putative risk factors. No UVR measures were significantly associated with NHL or NHL subtypes. Higher residential UVR levels during cohort follow-up were inversely associated with MM overall and among female patients (longitudinally updated HR per IQR increase: 0.74; 95% CI, 0.63-0.86) but not male patients (1.08; 95% CI, 0.90-1.29). Our results do not confirm an inverse association of adult ambient UVR levels with NHL risk. The MM findings require further investigation.<\/jats:p>","DOI":"10.1093\/aje\/kwae449","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:26:34Z","timestamp":1733729194000},"page":"3148-3157","source":"Crossref","is-referenced-by-count":1,"title":["Prospective pooled analyses of ambient ultraviolet radiation levels and risk of non-Hodgkin lymphoma and multiple myeloma"],"prefix":"10.1093","volume":"194","author":[{"given":"Sophia S","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Health Analytics, Beckman Research Institute, City of Hope , Duarte, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-7618","authenticated-orcid":false,"given":"Kimberly A","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Slone Epidemiology Center, Boston University , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4511-1452","authenticated-orcid":false,"given":"Emily L","family":"Deubler","sequence":"additional","affiliation":[{"name":"Department of Population Science, American Cancer Society , Atlanta, GA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun R","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation, Kaiser Permanente Southern California , Pasadena, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-5498","authenticated-orcid":false,"given":"Brenda M","family":"Birmann","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren R","family":"Teras","sequence":"additional","affiliation":[{"name":"Department of Population Science, American Cancer Society , Atlanta, GA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6907-0056","authenticated-orcid":false,"given":"Bernard A","family":"Rosner","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA ,","place":["United States"]},{"name":"Department of Biostatistics, Harvard TH Chan School of Public Health , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie","family":"McCullough","sequence":"additional","affiliation":[{"name":"Department of Population Science, American Cancer Society , Atlanta, GA ,","place":["United 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L","family":"Cauble","sequence":"additional","affiliation":[{"name":"Division of Health Analytics, Beckman Research Institute, City of Hope , Duarte, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpa V","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Population Science, American Cancer Society , Atlanta, GA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James V","family":"Lacey Jr.","sequence":"additional","affiliation":[{"name":"Division of Health Analytics, Beckman Research Institute, City of Hope , Duarte, CA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myles","family":"Cockburn","sequence":"additional","affiliation":[{"name":"Norris Comprehensive Cancer Center, University of Southern California , Los Angeles, CA ,","place":["United 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