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Understanding the impact of air pollution interventions on ASD incidence across neighborhood disadvantage levels can guide policies to protect vulnerable populations. We examined 2 sets of hypothetical particulate matter (PM)2.5 interventions: percentage reduction and regulatory standards as thresholds, to assess their potential effects on ASD cumulative incidence. Using G-computation under a counterfactual framework, we estimated changes in the cumulative incidence of ASD by age 5 under hypothetical interventions compared to observed exposures. Our study involved a birth cohort of 318\u2009298 children born between 2001-2014 in Southern California, with 4548 diagnosed with ASD by age 5. Pregnancy average PM2.5 and neighborhood disadvantage were assigned to residential addresses. Adjusted Cox regression models were applied to estimate ASD cumulative incidence. Reducing pregnancy average PM2.5 by 30% or below 9\u00a0\u03bcg\/m3 would have prevented 10.6 (95% CI, 3.6-19.2) and 12.5 (2.7-23.6) ASD cases per 10\u2009000 children, respectively. The decreases in ASD cumulative incidence under hypothetical interventions were similar across neighborhood disadvantage levels. These findings suggest that reducing ambient PM2.5 levels to meet or surpass current standards could help prevent ASD.<\/jats:p>","DOI":"10.1093\/aje\/kwae462","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T15:22:45Z","timestamp":1738855365000},"page":"689-698","source":"Crossref","is-referenced-by-count":1,"title":["The potential effects of hypothetical PM2.5 interventions on childhood autism in different neighborhood socioeconomic contexts"],"prefix":"10.1093","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-2324","authenticated-orcid":false,"given":"Xin","family":"Yu","sequence":"first","affiliation":[{"name":"Spatial Sciences Institute, University of Southern California , Los Angeles, CA 90089 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-3276","authenticated-orcid":false,"given":"Md Mostafijur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California , Los Angeles, CA 90032 ,","place":["United States"]},{"name":"Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine , 70112,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-1818","authenticated-orcid":false,"given":"Ting","family":"Chow","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-4172","authenticated-orcid":false,"given":"Frederick W","family":"Lurmann","sequence":"additional","affiliation":[{"name":"Sonoma Technology, Inc. , Petaluma, CA 94954 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-0557","authenticated-orcid":false,"given":"Jiu-Chiuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California , Los Angeles, CA 90032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-606X","authenticated-orcid":false,"given":"Mayra P","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Research & Evaluation, Kaiser Permanente Southern California , Pasadena, CA 91101 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6168-378X","authenticated-orcid":false,"given":"Joel","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Harvard T.H. Chan School of Public Health , Boston, MA 02115 ,","place":["United States"]},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-7880","authenticated-orcid":false,"given":"Sandrah P","family":"Eckel","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California , Los Angeles, CA 90032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California , Los Angeles, CA 90032 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-6410","authenticated-orcid":false,"given":"Rob","family":"McConnell","sequence":"additional","affiliation":[{"name":"Department of 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